胃肠肿瘤患者Ⅱ类切口围手术期预防使用抗菌药物的调查分析  

Investigation and Analysis on Preventive Antibacterials for Gastrointestinal Cancer Patients with Type Ⅱ Incisions During Perioperative Period

作　　者：刘小林[1] 谢铮铮[2] 邹梦迪 丁年羊[1] LIU Xiaolin;XIE Zhengzheng;ZOU Mengdi;DING Nianyang(Department of Clinical Pharmacy,Jiangsu Cancer Hospital/Jiangsu Institute of Cancer Research/Affiliated Cancer Hospital of Nanjing Medical University,Nanjing,Jiangsu,210009,China;Department of Pharmacy,Beijing Shijitan Hospital,Beijing,100038,China;School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing,Jiangsu,210009,China)

机构地区：[1]江苏省肿瘤医院/江苏省肿瘤防治研究所/南京医科大学附属肿瘤医院药学部临床药学室,江苏南京210009 [2]北京世纪坛医院药学部,北京100038 [3]中国药科大学基础医学与临床药学学院,江苏南京210009

出　　处：《肿瘤药学》2019年第5期804-808,共5页Anti-Tumor Pharmacy

摘　　要：目的评价胃肠肿瘤患者Ⅱ类切口手术围手术期抗菌药物的应用情况,为提高围手术期合理预防使用抗菌药物提供依据。方法采用回顾性调查方法,抽取我院2016年10月-2018年5月共128例Ⅱ类切口手术出院病历,对围手术期预防用药情况进行统计分析,并评价其合理性。结果128例Ⅱ类切口手术患者预防使用抗菌药物率达100%。不合理用药类型主要表现为选用品种不当(3.9%)、联合用药不适宜(39.06%)、给药时机不适宜(10.15%)、药物剂量不正确(28.91%)和预防用药疗程过长(80.47%)。结论胃肠肿瘤患者Ⅱ类切口手术围术期抗菌药物不合理应用主要表现为预防用药疗程过长,应采取质量管理工具等有效措施实施干预。Objective To evaluate the preventive antibacterials in gastrointestinal cancer patients with type II incisions during perioperative period,in order to provide references for improving the rationality of perioperative prophylactic use of antimicrobial agents.Methods A total of 128 patients with gastrointestinal cancer of typeⅡincision surgery were randomly selected in our hospital.Their clinical data were retrospectively analyzed.The statistical analysis on perioperative prophylaxis was conducted and its rationality was evaluated.Results All the 128 cases of typeⅡincision surgery had preventive antimicrobial agents,and the proportion was 100%.The types of irrational drug use mainly included improper selection of prophylactic drugs(3.9%),improper combination of drugs(39.06%),preoperative inappropriate timing of administration(10.15%),incorrect dosage(28.91%),and excessively long duration(80.47%).Conclusion The excessively long course of medication of preventive antimicrobial agents was found as the main manifestation of the perioperative irrational drug use for gastrointestinal cancer patients with typeⅡincision surgery.It is necessary to strengthen the rational drug use with effective intervention measures like quality management tools and so on.

关 键 词：胃肠道肿瘤 预防性抗菌药物 围手术期 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]