周围型与中央型广泛期小细胞肺癌患者的临床特征及生存分析  

Clinical characteristics and survival analysis of peripheral and central type extensive stage small cell lung cancer

作　　者：鲁璐 宋海珠 王亭 封冰 陈一天 王锐 韩思奇 付海京 褚晓源 LU Lu;SONG Haizhu;WANG Ting;FENG Bing;CHEN Yitian;WAN Rui;HAN Siqi;FU Haijing;CHU Xiaoyuan(Department of Medical Oncology,Jinling Hospital,Nanjing 210000,Jiangsu China)

机构地区：[1]东部战区总医院肿瘤内科

出　　处：《癌症进展》2019年第21期2531-2534,共4页Oncology Progress

摘　　要：目的探讨周围型与中央型广泛期小细胞肺癌(SCLC)患者的临床特征及生存分析。方法将99例广泛期SCLC患者根据影像学特征不同分为周围型组(n=46)和中央型组(n=53),分析周围型与中央型广泛期SCLC患者的临床特征及与预后的关系。结果周围型组患者的生存时间长于中央型组患者,差异有统计学意义(P﹤0.05);脑、肝、肺内转移阴性,体重升高及无变化的广泛期SCLC患者生存时间长于脑、肝、肺内转移阳性,体重下降的广泛期SCLC患者,差异均有统计学意义(P﹤0.05)。骨转移阳性与阴性的广泛期SCLC患者生存时间比较,差异无统计学意义(P﹥0.05)。Cox多因素分析结果显示:影像学特征分型为中央型、体重下降、脑转移、肝转移和肺内转移阳性是广泛期SCLC患者预后的独立危险因素(P﹤0.05)。结论影像学特征分型、体重、脑转移、肝转移和肺内转移阳性是广泛期SCLC患者预后独立危险因素,周围型广泛期SCLC患者生存时间优于中央型广泛期SCLC患者。Objective To investigate the clinical characteristics and survival of peripheral and central type extensive stage small cell lung cancer(SCLC).Method 99 patients with extensive stage SCLC were divided into the peripheral type group(n=46)and central type group(n=53)according to the imaging characteristics and the relationship of clinical characteristics in patients with peripheral type and central type extensive stage SCLC to the prognosis were analyzed.Result The survival time of peripheral type group was significantly longer than that of central type group,the difference is statistically significant(P<0.05).The survival time of extensive stage SCLC patients with brain,liver and lung metastasis negative and increased/stable weight was significantly longer than that of patients with brain,liver,lung metastasis positive,and weight loss(P<0.05).There was no significant difference for the survival time in positive and negative bone metastasis patients(P>0.05).The multivariate Cox analysis showed that imaging characteristics were divided into central type,weight loss,brain metastasis positive,liver metastasis positive and lung metastasis positive were independent risk factors of survival time for extensive stage SCLC patients(P<0.05).Conclusion The imaging characteristic based types,weight,brain,liver and lung metastasis positive were independent risk factors of prognosis in extensive stage SCLC.The survival time of patients with peripheral type extensive stage SCLC is longer than the central type patients.

关 键 词：小细胞肺癌 广泛期 预后 远处转移 

分 类 号：R734.2[医药卫生—肿瘤]