CPEB4在透明细胞性肾细胞癌中的表达及临床意义  被引量:1

Expression and clinical significance of CPEB4 in clear cell renal cell carcinoma

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作  者:王静[1] 王书芹[1] 周梅 毕超[1] 吕辉 禤瑞霞[1] 汪芸[1] 包贵贤[1] WANG Jing;WANG Shuqin;ZHOU Mei;BI Chao;LYU Hui;XUAN Ruixia;WANG Yun;BAO Guixian(Department of Pathology,Zhongshan Hospital of Traditional Chinese Medicine,Zhongshan 528400,Guangdong,China)

机构地区:[1]中山市中医院病理科

出  处:《癌症进展》2019年第21期2556-2560,共5页Oncology Progress

摘  要:目的探讨胞质多聚腺苷酸化元件结合蛋白4(CPEB4)在透明细胞性肾细胞癌(ccRCC)患者ccRCC组织中的表达情况及与患者临床特征和预后的关系。方法收集76例ccRCC患者的ccRCC组织及其中32例患者的癌旁(距肿瘤外缘≥5 cm)正常组织标本,采用实时定量聚合酶链反应(RT-PCR)和免疫组织化学染色法检测不同组织中CPEB4 mRNA和蛋白的表达情况,分析ccRCC组织中CPEB4 mRNA的阳性表达情况与ccRCC患者临床特征及预后的关系,以及ccRCC患者预后的影响因素。结果ccRCC患者ccRCC组织中CPEB4蛋白的高表达率和CPEB4 mRNA的阳性表达率均明显高于癌旁正常组织(P﹤0.01)。不同年龄、性别、肿瘤部位的ccRCC患者ccRCC组织中CPEB4 mRNA的阳性表达率比较,差异均无统计学意义(P﹥0.05);不同TNM分期、世界卫生组织(WHO)组织学分级和淋巴结转移情况的ccRCC患者ccRCC组织中CPEB4 mRNA的阳性表达率比较,差异均有统计学意义(P﹤0.05)。Cox比例风险模型分析结果显示,TNM分期为Ⅲ~Ⅳ期和CPEB4 mRNA阳性表达均是ccRCC患者预后的独立危险因素(P﹤0.05)。CPEB4 mRNA阴性表达患者的3年生存率明显高于CPEB4 mRNA阳性表达患者(P﹤0.01)。结论TNM分期为Ⅲ~Ⅳ期和CPEB4 mRNA阳性表达均是ccRCC患者预后的独立危险因素,CPEB4的表达情况对临床ccRCC治疗方案的选择及ccRCC患者预后的评估具有重要的临床指导价值。Objective To analyze the expression of cytoplasmic polyadenylation element binding protein 4(CPEB4)in the clear cell renal cell carcinoma(ccRCC)tissues of ccRCC patients,and to investigate the relationship with patients’clinical characteristics and prognosis.Method The ccRCC tissue from 76 patients with ccRCC and adjacent normal tissues(≥5 cm from the outer edge of tumor)from 32 cases out of the 76 ones were collected,subsequently,the expression of mRNA and protein of CPEB4 in different tissues were detected by real-time polymerase chain reaction(RT-PCR)and immunohistochemical assay,to determine the relationship between the positive expression of CPEB4 mRNA and patients’clinical characteristics,besides,the factors affecting the prognosis of ccRCC were also determined.Result The high expression rate of CPEB4 proteins and the positive expression of CPEB4 mRNA in ccRCC tissues were significantly higher than adjacent normal tissues,indicating statistically significant differences(P<0.01).The positive expression rate of CPEB4 mRNA in ccRCC tissues of ccRCC patients of different ages,genders and tumor site was not statistically significant(P>0.05).The positive expression rate of CPEB4 mRNA in ccRCC tissues of ccRCC patients with different TNM stages,WHO histological grades and lymph node metastasis were statistically significant(P<0.05).Cox proportional hazard model revealed that,TNM stage wasⅢ-Ⅳand positive expression of CPEB4 mRNA were independent risk factors for ccRCC patients(P<0.05).The three-year survival rate of patients with negative CPEB4 mRNA expression was significantly higher than patients with positive CPEB4 mRNA expression(P<0.01).Conclusion TNM stage isⅢ-Ⅳand positive expression of CPEB4 mRNA are independent risk factors for the prognosis of patients with ccRCC,furthermore,CPEB4 expression is clinically valuable for determining the therapy and evaluating prognosis for patients with ccRCC.

关 键 词:胞质多聚腺苷酸化元件结合蛋白4 透明细胞性肾细胞癌 临床特征 预后 

分 类 号:R737.11[医药卫生—肿瘤]

 

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