贝伐珠单抗对脑转移瘤放疗后顽固性脑水肿的疗效  

Therapeutic Effect of Bevacizumab on Intractable Encephaledema After Radiotherapy for Brain Metastases

作　　者：李忠喜 汪雪咏 LI Zhongxi;WANG Xueyong(Gamma Knife Treatment Center,Department of Radiotherapy,Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangshu 221000,China)

机构地区：[1]徐州医科大学附属医院放疗科伽玛刀治疗中心,江苏徐州221000

出　　处：《大医生》2019年第10期5-6,共2页Doctor

摘　　要：目的探讨贝伐珠单抗对脑转移瘤放疗后顽固性脑水肿的治疗作用。方法选取2017年1月至2018年6月徐州医科大学附属医院收治的40例脑转移瘤放疗后或伽玛刀治疗后顽固性脑水肿患者。随机分两组,每组20例。对照组采取常规药物治疗,干预组则采取常规药物+贝伐珠单抗治疗。比较两组临床疗效。结果治疗后,与对照组比较,干预组总有效率明显升高(95.00%vs.75.00%),脑水肿体积及水肿指数明显减少,卡氏评分明显增加,水肿体积减少一半的时间及症状好转时间明显缩短,差异均有统计学意义(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论贝伐珠单抗治疗脑转移瘤放疗后顽固性脑水肿效果较好。Objective To investigate the therapeutic effect of bevacizumab on intractable encephaledema after radiotherapy for brain metastases.Methods Forty patients with intractable encephaledema after brain metastases or after gamma knife treatment from January 2017 to June 2018 in our hospital were selected.They were randomly divided into two groups,20 cases per group.The control group received conventional drug therapy,while the intervention group received conventional drug+bevacizumab.The effects of the two groups were compared.Results After treatment,compared with the control group the total effective rate of the intervention group was significantly increased(95.00%vs.75.00%),the volume of edema and edema index were significantly decreased,and the Karlsfeld score was significantly increased,the time to reduce the volume of edema and to improve symptom were significantly shortened(P<0.05).There was no significant difference in incidence of complicationsbetween the two groups(P>0.05).Conclusion Bevacizumab had a good effect on intractable encephaledema after radiotherapy for brain metastases.

关 键 词：贝伐珠单抗 脑转移瘤 放疗 顽固性脑水肿 治疗作用 

分 类 号：R73[医药卫生—肿瘤]