Piwil2在三阴性乳腺癌中的表达及与临床分期、肿瘤直径及淋巴结转移的关系  

Expression of Piwil2 in Triple-negative Breast Cancer and its Relationship with Clinical Stage、Tumor Diameter and Lymph Node Metastasis

作　　者：刘起胜[1] 徐妮为[1] 邹艳[1] 黄旭[1] 徐筱红[1] 曹寅生[2] LIU Qisheng;XU Niwei;ZOU Yan;HUANG Xu;XU Xiaohong;CAO Yinsheng(Department of Basic Medicine,Hunan College of Traditional Chinese Medicine,Zhuzhou,Hunan 412012,China;Department of Orthopaedics and Traumatology,the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha,Hunan 410007,China)

机构地区：[1]湖南中医药高等专科学校基础医学部,湖南株洲412012 [2]湖南中医药大学第一附属医院骨伤科,湖南长沙410007

出　　处：《大医生》2019年第10期14-15,共2页Doctor

基　　金：湖南教育厅基金项目:PIWIL2在三阴性乳腺癌中的表达及意义(16C1255)。

摘　　要：目的探讨Piwil2在三阴性乳腺癌(TNBC)中的表达及与临床分期、肿瘤直径及淋巴结转移的关系。方法从选取2016年3月至2018年3月在湖南中医药大学第一附属医院治疗的40例患者为研究对象,对其进行Piwil2检测,观察不同临床分期、肿瘤直径及淋巴结转移患者的Piwil2表达情况。结果40例中Piwil2阳性率为70.00%。不同临床分期的TNBC患者Piwil2表达有明显差异(P<0.05);肿瘤直径越大、淋巴结转移患者的Piwil2阳性表达率明显较高(P<0.05)。结论TNBC的Piwil2阳性表达率较高,且随着临床分期越高、肿瘤直径越大、淋巴结转移,其阳性率表达率越高。Objective To investigate the expression of Piwil2 in triple negative breast cancer(TNBC)and its relationship with clinical stage,tumor diameter and lymph node metastasis.Methods The expression of Piwil2 with tumor diameter,lymph node metastasis and different clinical stages were observed by detecting the expression of Piwil2 in 40 patients with pathologic wax block of TNBC.Results The positive rate of Piwil2 in 40 cases was 70.00%.The expression of Piwil2 in TNBC patients with different clinical stages was significantly different(P<0.05).The larger the tumor diameter,the higher the expression rate of Piwil2 in patients with lymph node metastasis(P<0.05).Conclusion The positive expression rate of Piwil2 in TNBC was higher,and positively related to the clinical stage,the tumor diameter and the lymph node metastasis.

关 键 词：Piwil2 三阴性乳腺癌 肿瘤 淋巴转移 阳性率 

分 类 号：R73[医药卫生—肿瘤]