同步放化疗与序贯化放疗治疗Ⅲ期非手术小细胞肺癌的临床疗效  

Efficacy of Concurrent Chemoradiotherapy and Sequential Radiotherapy for Stage Ⅲ Non-surgical Small Cell lung Cancer

作　　者：李韦[1] LI Wei(Guanyun County People's Hospital,Lianyungang City,Guanyun,Jiangsu 222200,China)

机构地区：[1]江苏省连云港市灌云县人民医院,江苏灌云222200

出　　处：《大医生》2019年第9期34-35,38,共3页Doctor

摘　　要：目的分析比较同步放化疗与序贯化放疗治疗在Ⅲ期不能手术的非小细胞肺癌患者临床治疗中的应用效果。方法选取90例Ⅲ期不能手术非小细胞肺癌患者,随机分为两组,每组45例。同步放化疗组实施同步放化疗,序贯化放疗组予以序贯化放疗治疗。比较两组患者的KPS评分、近期疗效及不良反应发生情况。结果治疗前两组功能状态评分标准(Karnofsky,KPS)评分比较差异无统计学意义(P>0.05);治疗后两组经KPS评分并与本组治疗前比较均明显增加,且同步放化疗组显著高于序贯化放疗组(P<0.05)。同步放化疗组治疗总有效率明显高于序贯化放疗组(P<0.05)。同步放化疗组不良反应发生情况明显少于序贯化放疗组(P<0.05)。结论与序贯化放疗治疗相比较,对Ⅲ期不能手术非小细胞肺癌患者实施同步放化疗治疗效果更为为理想。Objective To analyze and compare the effect of synchronous radiotherapy and chemotherapy and sequential chemo-radiotherapy in the treatment of stage Ⅲ non-small cell lung cancer(NSCLC).Methods Ninety patients with stage Ⅲ unsurgical NSCLC were selected and randomly divided into two groups,each group 45 cases.The synchronous radiotherapy and chemotherapy group was treated with synchronous radiotherapy and chemotherapy,and the sequential radiotherapy group was treated with sequential chemo-radiotherapy.KPS scores,short-term efficacy and adverse reactions were compared between the two groups.Results There was no significant difference in Karnofsky(KPS)scores between the two groups before treatment(P>0.05).After treatment,KPS scores of the two groups were significantly increased compared with that of the group before treatment,and the concurrent chemoradiotherapy group was significantly higher than that of the sequential radiotherapy group(P<0.05).The total effective rate of concurrent chemoradiotherapy group was significantly higher than that of sequential radiotherapy group(P<0.05).The incidence of adverse reactions in the concurrent chemoradiotherapy group was significantly lower than that in the sequential radiotherapy group(P<0.05).Conclusion Compared with sequential chemo-radiotherapy treatment,synchronous radiotherapy and chemotherapy therapy effect is more ideal for stage Ⅲ unsurgical NSCLC patients.

关 键 词：非小细胞肺癌 Ⅲ期 不能手术 序贯化放疗 同步放化疗 

分 类 号：R73[医药卫生—肿瘤]