替罗非班联合阿替普酶治疗急性缺血性卒中患者的疗效及安全性  

Clinical Effect and Safety of Tirofiban Combined with Alteplase in the Treatment of Patients with Acute Ischemic Stroke

作　　者：陈孝伟[1] CHEN Xiaowei(Department of Neurology,Liaocheng Second People's Hospital Affiliated to Taishan Medical College,Linqing,Shandong 252600,China)

机构地区：[1]泰山医学院附属聊城市第二人民医院神经内科,山东临清252600

出　　处：《大医生》2019年第5期119-121,共3页Doctor

摘　　要：目的探讨替罗非班联合阿替普酶治疗急性缺血性卒中患者的有效性及安全性。方法选取泰山医学院附属聊城市第二人民医院神经内科确诊的60例急性缺血性卒中患者,随机分为联合治疗组(阿替普酶联合替罗非班)和对照组(阿替普酶),每组30例。治疗前和治疗后24 h、14 d、3个月,观察并比较两组患者美国国立卫生研究院卒中量表(NHISS)评分、生活能力评分(MRS)及不良反应发生情况。结果治疗后24 h后,联合治疗组临床好转率高于对照组,改善后加重率低于对照组,两组比较差异均有统计学意义(P<0.05)。治疗后24 h、14 d、3个月,联合治疗组NHISS、MRS评分均低于同期对照组,两组比较差异有统计学意义(P<0.05);两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论阿替普酶联合替罗非班治疗急性缺血性卒中临床疗效显著,能够明显改善患者的神经功能,并不增加出血风险。Objective To investigate the effect and safety of tirofiban combined with alteplase in the treatment of patients with acute ischemic stroke.Methods Sixty patients with acute ischemic stroke admitted to the Department of Neurology,Liaocheng Second People's Hospital Affiliated to Taishan Medical College were randomly divided into the combined group(alteplase plus tirofiban)and control group(alteplase),30 cases per group.The National Institutes of Health Stroke Scale(NHISS)scores life ability scores(MRS),and adverse reactions of the two groups were compared before treatment and 24 h,14 d,and 3 months after treatment.Results The clinical improvement rate of the combined group was higher than the control group,while the aggravation rate after improvement was lower than the control group(P<0.05).The scores of NHISS and MRS in the combination group and the control group were decreased at 24 h,14 d and 3 months.There was significant difference between the two groups(P<0.05).There was no statistical difference in the adverse reactions between the two groups(P>0.05).Conclusion Alteplase combined with tirofiban was effective in the treatment of acute ischemic stroke,which can significantly improve the neurological function of patients without increasing the risk of bleeding.

关 键 词：急性缺血性卒中 阿替普酶 替罗非班 美国国立卫生研究院卒中量表 安全性 

分 类 号：R74[医药卫生—神经病学与精神病学]