白细胞介素-1基因多态性与侵袭性牙周炎的关系  

The Relationship between Interleukin-1 Gene Polymorphism and Aggressive Periodontitis

作　　者：陈春生 娄新华 叶俊 CHEN Chunsheng;LOU Xinhua;YE Jun(Stomatology Department,Seventh People's Hospital of Shanghai University of TCM,Shanghai 200137,China)

机构地区：[1]上海市中医药大学附属第七人民医院,上海200137

出　　处：《大医生》2019年第11期127-128,共2页Doctor

摘　　要：目的分析白细胞介素-1(IL-1)基因多态性与侵袭性牙周炎的关系,探讨侵袭性牙周炎发生机制。方法选取临床样本105例侵袭性牙周炎患者为病例组,105例无侵袭性牙周炎患者为对照组,采集肘部静脉血,提取DNA,PCR法检测IL-1B-511、IL-1B+3954、IL-1RN基因分型,进行组间对比。结果病例组与对照组IL-1B-511、IL-1B+3954、IL-1RN基因分型分布,IL-1B+3954 C位点与T位点分布,差异无统计学意义(P>0.05)。病例组IL-1B-511中C位点显示率低于对照组,差异有统计学意义(P<0.05)。结论IL-1B-51 C位点可能会增加侵袭性牙周炎的发病危险因素。Objective To analyze the relationship between interleukin-1(IL-1)gene polymorphism and aggressive periodontitis(AgP),and to explore the pathogenesis of aggressive periodontitis.Methods One hundred and five patients with AP were selected as AP group,and 105 cases without AP were selected as control group.Clincal samples were collected from elbow veins of all subjects and DNA was extracted.The genotypes of IL-1B-511,IL-1B+3954 and IL-1RN were detected by PCR and compared among the two groups.Results There was no significant difference in genotyping distribution of IL-1B-511,IL-1B+3954,IL-1RN and distribution of IL-1B+3954 C and T loci between the case group and control group.The C locus display rate of IL-1B-511 in the case group was lower than that in the control group(P<0.05).Conclusion IL-1B-51 C locus may increase the risk factors of aggressive periodontitis.

关 键 词：侵袭性牙周炎 基因多肽性 白细胞介素-1 

分 类 号：R78[医药卫生—口腔医学]