丹红注射液与银杏内酯注射液治疗缺血性脑卒中临床效果观察  

Clinical Efficacy of Danhong Injection and Ginkgolide Injection in the Treatment of Ischemic Stroke

作　　者：冯荣伟 王文习 范艳平 马影 贾丽霞 FENG Rong-wei;WANG Wen-xi;FAN Yang-ping;MA Ying;JIA Li-xia(Department of Pharmacy,980 Hospital of PLA Joint Logistics Support Forces,Shijiazhuang 050082,China;The Third Division of Cadre Ward,980 Hospital of PLA Joint Logistics Support Forces,Shijiazhuang 050082,China)

机构地区：[1]中国人民解放军联勤保障部队第九八〇(白求恩国际和平)医院药剂科,石家庄050082 [2]中国人民解放军联勤保障部队第九八〇(白求恩国际和平)干部病房三科,石家庄050082

出　　处：《临床误诊误治》2019年第11期39-43,共5页Clinical Misdiagnosis & Mistherapy

基　　金：河北省中医药管理局科研计划项目(2019192)

摘　　要：目的观察比较丹红注射液与银杏内酯注射液治疗缺血性脑卒中的临床效果。方法选取缺血性脑卒中296例,采用随机数字表法随机将其分为观察组和对照组两组各148例。观察组在常规治疗基础上给予丹红注射液治疗,对照组在常规治疗基础上给予银杏内酯注射液治疗。两组均治疗14 d。观察比较两组治疗前和治疗后14 d美国国立卫生研究院卒中量表(NIHSS)评分,治疗前和治疗后90 d Barthel指数评分,治疗后90 d临床效果,治疗前和治疗后14 d血浆脑钠肽(BNP)和心钠肽(ANP)水平,以及治疗后90 d内并发症发生情况。结果治疗前,两组NIHSS、Barthel指数评分及血浆BNP、ANP水平比较差异均无统计学意义(P>0.05)。治疗后14 d,两组NIHSS评分和血浆BNP、ANP水平均较治疗前降低,治疗前和治疗后14 d两组组内NIHSS评分和血浆BNP、ANP水平比较差异有统计学意义(P<0.05);治疗后90 d,两组Barthel指数评分均较治疗前升高,治疗前和治疗后90 d两组组内Barthel指数评分比较差异亦有统计学意义(P<0.05)。治疗后14 d,观察组NIHSS评分和血浆BNP、ANP水平均低于对照组;治疗后90 d,观察组Barthel指数评分高于对照组,差异有统计学意义(P<0.05)。治疗后90 d,观察组总有效率明显高于对照组,差异具有统计学意义(P<0.05)。治疗后90 d内,观察组总并发症发生率高于对照组,差异具有统计学意义(P<0.05)。结论丹红注射液与银杏内酯注射液均可以治疗缺血性脑卒中,治疗效果丹红注射液明显好于银杏内酯注射液,但是并发症发生率也较高。Objective To investigate and compared the clinical efficacy of Danhong injection and ginkgolide injection in the treatment of patients with ischemic stroke. Methods A total of 296 patients with ischemic stroke were randomly divided into observation group(n=148) and control group(n=148), according to random number table method. On the basis of conventional treatment, the observation group was treated with Danhong injection, and the control group was given ginkgolide injection. The course of treatment for both groups was 14 d. The National Institutes of Health Stroke Scale(NIHSS) scores before and at 14 d after treatment, and Barthel index score before and at 90 d after treatment were compared. Clinical efficacy at 90 d after treatment, plasma brain natriuretic peptide(BNP) and atrial natriuretic peptide(ANP) levels before and at 14 d after treatment and the occurrence of complications within 90 d after treatment were compared between two groups. Results Before treatment, there were no significant differences in NIHSS, Barthel index scores and plasma BNP and ANP levels between the two groups(P>0.05). Before treatment and at 14 d after treatment, there were significant differences in the NIHSS scores and plasma BNP and ANP levels between the two groups(P<0.05). At 90 d after treatment, the Barthel index scores were higher than those before treatment, and the difference between two groups was also statistically significant(P<0.05). At 14 d after treatment, the NIHSS score and plasma BNP and ANP levels in the observation group were significantly lower than those in the control group, and at 90 d after treatment, the Barthel index scores of the observation group were significantly lower than those of the control group(P<0.05). At 90 d after treatment, the total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant(P<0.05). At 90 d after treatment, the incidence of total complications was higher in the observation group than in t

关 键 词：丹红注射液 银杏内酯注射液 卒中 缺血性 

分 类 号：R743[医药卫生—神经病学与精神病学]