依达拉奉注射液用于治疗急性脑梗死患者的疗效和安全性分析  

Efficacy and safety of edaravone injection in treatment of acute cerebral infarction

作　　者：周翠萍 高岱佺[2] 刘芳[1] 汪慧 ZHOU Cuiping;GAO Daiquan;LIU Fang(Department of Neurology,The First Affiliated Hospital of Tsinghua University,Beijing 100016,China)

机构地区：[1]清华大学第一附属医院神经内科,北京市100016 [2]首都医科大学宣武医院神经内科

出　　处：《河北医药》2019年第22期3444-3447,共4页Hebei Medical Journal

摘　　要：目的探讨依达拉奉注射液治疗急性脑梗死的疗效和安全性。方法选择急性脑梗死患者96例按照随机数字表法分为研究组与对照组,每组48例。对照组采用常规治疗方法治疗,研究组在此基础上采用依达拉奉注射液治疗。比较2组的临床疗效、治疗前后超氧化物歧化酶(SOD)、内皮素-1(ET-1)和丙二醛(MDA),以及白介素(IL)-6、IL-2、IL-13水平及不良反应发生情况。结果治疗后2组临床疗效比较,研究组显著高于对照组(P<0.05);2组的NIHSS和BI评分均改善,且研究组的改善程度更加显著(P<0.05);2组的自由基水平和炎性因子均改善,且研究组的改善程度更加显著(P<0.05);2组间的安全性情况差异无统计学意义(P>0.05)。结论依达拉奉注射液治疗急性脑梗死具有良好的效果,调节炎性反应和减少自由基损伤,恢复患者的神经功能及日常生活能力;安全性较好。Objective To investigate the efficacy and safety of edaravone injection in treatment of acute cerebral infarction.Methods A total of 96 patients with acute cerebral infarction who were treated in our hospital from October 2015 to October 2018 were enrolled in the study,who were divided into research group(n=48)and control group(n=48)according to random number table method.The patients in control group were treated by conventional therapy,and the patients in research group,on the basis of control group,were treated by edaravone injection.The clinical efficacy,the levels of SOD,ET-1 and MDA,IL-6,IL-2 and IL-13 before and after treatment,and the incidence rate of adverse reactions were observed and compared between the two groups.Results After treatment,the clinical efficacy in research group was significantly higher than that in control group(P<0.05),and the NIHSS scores and BI scores were improved in both groups,moreover,the improvement degree in research group was more significant than that in control group(P<0.05).In addition the free radicals and inflammatory cytokines were improved in both groups,and the improvement degree in research group was more significant than that in control group(P<0.05).There was no significant difference in safety between the two groups(P>0.05).Conclusion Edaravone injection has better therapeutic effects on acute cerebral infarction,which can regulate inflammatory response,reduce free radical injury,recover patients’neurological function and daily living ability of patients,with good safety.

关 键 词：依达拉奉 急性脑梗死 炎症反应 自由基 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]