低T3综合征与急性脑梗死严重程度及死亡的相关性研究  

Study on correlation of low T3 syndrome to severity and death of acute cerebral infarction

作　　者：鲁远君 李小荣 费容 文治成 曾建涛 宋金玲 LU Yuanjun;LI Xiaorong;FEI Rong;WEN Zhicheng;ZENG Jiantaog;SONG Jinling(Department of Neurology;Department of Clinical Laboratory,Changshou District People′s Hospital,Chongqing 401220,China)

机构地区：[1]重庆市长寿区人民医院神经内科,401220 [2]重庆市长寿区人民医院检验科,401220

出　　处：《重庆医学》2019年第21期3662-3665,共4页Chongqing medicine

基　　金：重庆市卫生健康委科研项目(2015ZBXM074)

摘　　要：目的探讨低T3综合征在急性脑梗死严重程度及死亡的相关性。方法选取2015年1月至2016年12月该院神经内科收治的急性脑梗死患者177例为研究对象,同期健康体检者168例作为健康对照。分别在入院第2天清晨抽取空腹肘静脉血3 mL,采用放射免疫分析法测定血清总三碘甲状腺原氨酸(TT3)、游离三碘甲腺原氨酸(FT3)、总甲状腺素(TT4)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平;采用美国国立卫生研究院卒中量表(NIHSS)对患者神经功能缺损程度进行评估;分析各组低T3综合征构成情况及临床资料。结果脑梗死组低T3综合征构成比明显高于对照组,差异有统计学意义(χ^2=11.533,P=0.001)。轻、中、重度脑梗死组低T3综合征构成比差异有统计学意义(χ^2=12.920,P=0.002)。中、重度脑梗死存活组与死亡组低T3综合征构成比差异无统计学意义(χ^2=3.523,P=0.061)。结论低T3综合征的发生率与脑梗死的严重程度相关,而与脑梗死患者死亡无关。Objective To investigate the incidence rate of low T3 syndrome in the patients with acute cerebral infarction and its correlation with severity and death of cerebral infarction.Methods A total of 177 patients with acute cerebral infarction in the neurology department of this hospital from January 2015 to December 2016 were selected as the study subjects,and contemporaneous 168 healthy people undergoing physical examination were served as the control group.Fasting venous blood 3 mL was taken on the second day after admission.The serum levels of TT3,FT3,TT4,FT4 and TSH were detected by using the radioimmunoassay.The neurologic function impairment degree was detected by using NIHSS.The constitution situation of low T3 syndrome and clinical data in each group were analyzed.Results The constituent ratio of low T3 syndrome in the cerebral infarction group was significantly higher than that in the control group,and the difference was statistically significant(χ^2=11.533,P=0.001).The ratio of low T3 syndrome had statistical difference among the mild,moderate and severe cerebral infarction groups(χ^2=12.920,P=0.002).There was no statistically significant difference in the constituent ratio of low T3 syndrome between the moderate and severe cerebral infarction groups with the death group(χ^2=3.523,P=0.061).Conclusion The incidence rate of low T3 syndrome is related to the severity of cerebral infarction,and has no relation with the death in the patients with cerebral infarction.

关 键 词：脑梗死 功能正常甲状腺病综合征 死亡 

分 类 号：R743.32[医药卫生—神经病学与精神病学]