双源CT灌注成像在肝癌经导管动脉化疗栓塞术后疗效评估中的应用  

Application of dual-source CTPI in curative effect assessment post TACE of liver cancer

作　　者：周存凉[1] 丁勇生[1] ZHOU Cun-liang;DING Yong-sheng(Imaging Department,Nantong Tumor Hospital,Nantong 226006,China)

机构地区：[1]南通市肿瘤医院影像科

出　　处：《中国医学装备》2019年第11期59-62,共4页China Medical Equipment

摘　　要：目的:探讨双源CT全肝灌注成像(CTPI)对原发性肝癌患者经导管肝动脉化疗栓塞(TACE)术治疗效果的评估价值。方法:选取在医院就诊并行TACE术的35例(40个病灶)肝癌患者,分别于术前3 d、术后7 d及术后30 d行双源CTPI扫描,观察治疗前后病灶的门静脉灌注量(PVP)、肝动脉灌注量(HAP)及肝动脉灌注指数(HPI)的灌注参数变化。结果:术后在35例患者中有15例患者的18个病灶被碘油完全栓塞,20例患者的22个病灶未被碘油完全栓塞;碘油栓塞区病灶的HAP、HPI值明显低于碘油稀疏区,差异有统计学意义(t=17.421,t=18.841;P<0.05),PVP值明显高于术后碘油稀疏区(t=14.417,P<0.05);碘油稀疏区病灶术后30 d的HAP、HPI值高于术后7 d,差异具有统计学意义(t=4.324,t=3.525;P<0.05),术后30 d与术后7 d的PVP值比较差异无统计学意义(t=1.095,P>0.05)。结论:双源CTPI对原发性肝癌患者TACE术后疗效评估及术后残余病灶监测有重要意义。Objective:To explore assessment value of dual-source computed tomography perfusion imaging(CTPI)in curative effect of transcatheter arterial chemoembolization(TACE)on patients with primary liver cancer.Methods:35 patients(40 lesions)with liver cancer who were treated and underwent TACE in hospital were enrolled.They were scanned by dual-source CTPI at 3 d pre surgery,at 7 d and 30 d post surgery.The changes of perfusion parameters included portal venous perfusion(PVP),hepatic arterial perfusion(HAP)and hepatic perfusion index(HPI)of lesions between before and after treatment were observed.Results:After surgery,there were 15 cases(18 lesions)had entire embolism with lipiodol,and 20 cases(22 lesions)had not entire embolism with lipiodol.The HAP and HPI of lesions in embolization area of lipiodol were significantly lower than those in sparse area of lipiodol(t=17.421,t=18.841,P<0.05),while PVP of embolization area of lipiodol was significantly higher than that of sparse area of lipiodol(t=14.417,P<0.05).HAP and HPI at 30 d post surgery of sparse area of lipiodol were significantly higher than those at 7 d post surgery of the same area(t=4.324,t=3.525,P<0.05),while there was no significant difference in PVP between the two time points(t=1.095,P>0.05).Conclusion:Dual-source CTPI has important significance in curative effect assessment post surgery of patients with primary liver cancer who receive TACE and in monitoring postoperative residual lesions of patients.

关 键 词：双源CT全肝灌注成像 原发性肝癌 经导管肝动脉化疗栓塞术 疗效 

分 类 号：R735.7[医药卫生—肿瘤]