18F-FDG PET/CT代谢参数与结直肠癌临床病理特征的关系  

Relation Between Metabolic Parameters of 18F-FDG PET/CT and Clinicopathological Features of Colorectal Cancer Patients

作　　者：宋金龄 李忠武[2] 卫毛毛 周妮娜[1] 杨志[1] 王雪鹃[1] SONG Jinling;LI Zhongwu;WEI Maomao;ZHOU Ni’na;YANG Zhi;WANG Xuejuan(Department of Nuclear Medicine,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Peking University Cancer Hospital&Institute,Beijing 100142,China;Department of Pathology,Peking University Cancer Hospital&Institute,Beijing 100142,China;Department of Nuclear Medicine,Zhejiang Cancer Hospital,Hangzhou 310021,China)

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科,恶性肿瘤发病机制及转化研究部重点实验室,北京100142 [2]北京大学肿瘤医院暨北京市肿瘤防治研究所病理科,北京100142 [3]浙江省肿瘤医院核医学科,杭州310021

出　　处：《肿瘤防治研究》2019年第11期1006-1012,共7页Cancer Research on Prevention and Treatment

摘　　要：目的探讨18F-FDG PET/CT代谢参数与结直肠癌临床病理特征的关系。方法纳入358例CRC患者行治疗前18F-FDG PET/CT显像,测量CRC原发灶最大标准摄取值、平均标准摄取值、肿瘤代谢体积和病灶糖酵解总量,分析其与原发灶位置、病理特征及TNM分期的关系。结果结肠癌原发灶MTV及TLG值最高,乙状结肠癌次之,直肠癌最低,组间差异有统计学意义(P<0.001)。低/中低分化直肠癌SUVmax值高于中/高分化直肠癌(P=0.028)。黏液腺癌原发灶MTV值较普通型腺癌大(P=0.023)。T4期原发灶MTV和TLG值高于T2-3期病灶(P=0.0001,P=0.007)。存在远处转移的乙状结肠癌原发灶SUVmax及SUVmean低于无远处转移者(P=0.015,P=0.011)。结论CRC原发灶代谢参数与位置、病理特征及TNM分期相关,能部分反映肿瘤病理特征,揭示CRC异质性。Objective To investigate the relation between 18F-FDG PET/CT metabolic parameters and the clinicopathological characteristics of colorectal cancer(CRC)patients.Methods We included 358 CRC patients who met the admission criteria.18F-FDG PET/CT scans were performed before any treatment.Maximum standard uptake,average standard uptake,tumor metabolic volume(MTV)and total glycolysis(TLG)of the primary lesion of CRC were measured and calculated.The correlation of metabolic parameters with lesion location,pathological profile and TNM staging were investigated through Mann-Whitney U test and Kruskal-Wallis test.Results The MTV and TLG values in the primary foci of colon cancer were the highest,followed by sigmoid cancer and the lowest in rectal cancer,with statistically significant differences between the groups(P<0.001).SUVmax values of poorly/poorly-moderately differentiated colorectal cancer were higher than those of moderately/well differentiated colorectal cancer(P=0.028).MTV values of primary mucinous adenocarcinoma were higher than those of primary adenocarcinoma(P=0.023).MTV and TLG values were higher in T4 lesions than those in T2-3 lesions(P=0.0001,P=0.007);SUVmax and SUVmean values of sigmoid carcinoma with distant metastasis were lower than those without distant metastasis(P=0.015,P=0.011).Conclusion The metabolic parameters of CRC are correlated with the lesion location,pathological features and TNM staging,which could partly reflect the pathological characteristics and heterogeneity of CRC.

关 键 词：结直肠癌 正电子发射计算机断层显像 代谢参数 临床病理特征 

分 类 号：R735.3[医药卫生—肿瘤]