阿茨海默病患者睡眠结构异常与认知功能MMSE、MoCA评分的相关性研究  

Correlation between Sleep Structure Abnormalities and Cognitive Function Scores(MMSE and MoCA)in Patients with Alzheimer's Disease

作　　者：李怀苏[1] 周雯 曾天芳 杨丹[1] LI Huai-su;ZHOU Wen;ZENG Tian-fang(Department of Neurology,Second People's Hospital of Chengdu,Sichuan 610017,China)

机构地区：[1]成都市第二人民医院神经内二科,四川成都610017

出　　处：《医学临床研究》2019年第10期1890-1892,共3页Journal of Clinical Research

摘　　要：【目的】探讨阿茨海默病(AD)患者睡眠结构异常与认知功能的相关性.【方法】选取2016年1月至2018年12月在本院就诊的AD患者100例,其中合并睡眠结构异常患者50例(观察组),单纯AD患者50例(对照组).比较两组患者睡眠参数指标变化情况;采用蒙特利尔认知评估量表(MoCA)和简易智力状况检查量表(MMSE)评价患者的认知功能;采用Spearman相关分析方法分析AD患者睡眠结构异常和认知功能的相关性.【结果】两组醒觉时间、NREM 2期、NREM 1+2期所占比例比较差异无显著性(P>0.05);与对照组相比,观察组NREM 1期、NREM期所占比例明显升高(P<0.05),NREM 3+4期、REM期期、MMSE评分、MoCA评分明显降低(P<0.05).观察组患者MMSE评分与NREM 3+4期、夜间最低动脉血氧饱和度(SaO2)、夜间平均SaO2呈正相关(P<0.05),与NREM 1+2期、ODI、AHI呈负相关(P<0.05),与REM期、微觉醒指数没有线性关系.MoCA评分与夜间平均SaO2和夜间最低SaO2呈正相关(P<0.05),与INREM 1+2期、血氧饱和度下降指数(ODI)、呼吸暂停通气指数(AHI)呈负相关(P<0.05).MoCA评分与微觉醒指数、ODI呈负相关(P<0.05),与REM期呈正相关(P<0.05),与夜间最低SaO2、夜间平均SaO2、NREM 1+2期、NREM 3+4期、AHI无线性相关(P>0.05).【结论】老年痴呆患者睡眠结构出现异常,认知功能下降,其睡眠结构变化与认知功能可能存在相关性.【Objective】To investigate the relationship between sleep structure abnormalities and cognitive function in patients with Alzheimer's disease.【Methods】A total of 100 patients with Alzheimer's disease who were treated in our hospital from January 2016 to December 2018 were enrolled,including 50 patients with senile dementia with sleep structural abnormalities(the observation group)and 50 patients with senile dementia without sleep structural abnormalities(the control group).The changes in sleep parameters were compared between the two groups,and the cognitive function was assessed by using both Montreal Cognitive Assessment Scale(MoCA)and Mini-Mental State Examination(MMSE).The Spearman correlation was used to analyze the correlation between sleep structural abnormalities and cognitive function in patients with Alzheimer's disease.【Results】There was no significant difference in the proportion of wake-up time,NREM 2 phase,and NREM 1+2 phase between the two groups(P>0.05).Compared to the control group,the proportion of NREM 1 phase and NREM phase in the observation group was significantly increased(P<0.05)and the proportion of the NREM 3+4 phase,REM,MMSE,and MoCA scores were significantly lower(P<0.05)in the observation group.The MMSE score of the observation group was positively correlated with NREM 3+4 phase,the nighttime minimum SaO2,and the average SaO2 at night(P<0.05),however,the MMSE score of the observation group was negatively correlated with NREM phase 1+2,ODI,AHI(P<0.05).There was no linear correlation of MMSE with REM phase and micro-awakening index(P>0.05).On the other hand,the MoCA score was positively correlated with the nighttime minimum SaO2 and nighttime average SaO2(P<0.05),and negatively correlated with INREM 1+2 phase,oxygen saturation decline index(ODI)and apnea ventilation index(AHI)(P<0.05).The MoCA score was negatively correlated with micro-awakening index and ODI(P<0.05),and positively correlated with the REM phase(P<0.05),and no linearly correlated with the nighttime minimum SaO

关 键 词：阿尔茨海默病/病理生理学 睡眠觉醒障碍 认知 

分 类 号：R745.1[医药卫生—神经病学与精神病学]