唾液巨噬细胞迁移抑制因子水平与原发性干燥综合征的相关性研究  

The correlation between salivary macrophage migration inhibitory factor levels and primary Sj?gren′s syndrome

作　　者：强璐 王雨萌 裴婷婷 QIANG Lu;WANG Yumeng;PEI Tingting(Department of Stomatology,Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学第三附属医院口腔科

出　　处：《中国医药导报》2019年第28期103-105,117,共4页China Medical Herald

基　　金：国家重点基础研究发展计划（2014CB543003）;北京中医药大学中青年教师资助项目（2011-JYB22-JS125）

摘　　要：目的检测原发性干燥综合征(pSS)患者唾液巨噬细胞迁移抑制因子(MIF)水平并探讨与疾病严重性的关系。方法纳入2009年10月~2018年10月于北京中医药大学第三附属医院(以下简称“我院”)确诊的pSS患者作为pSS组(96例);另纳入我院同期年龄及性别匹配的健康人群作为对照组(70名)。评价pSS患者疾病活动度,比较各组唾液MIF水平,评价唾液MIF水平与pSS发病的关系,分析唾液MIF水平与干燥综合征评分(ESSDAI评分)的相关性。结果pSS组唾液MIF水平显著高于对照组,差异有高度统计学意义(P<0.01)。唾液MIF水平是pSS的独立危险因素[OR(95%CI)=1.996(1.339~2.977),P<0.01]。唾液MIF水平与ESSDAI评分呈正相关(r=0.276,P<0.01)。结论唾液MIF水平有望作为预测pSS发生发展的重要生物标志物。Objectives To detect salivary macrophage migration inhibitory factor(MIF)level in patients with primary SjOgren's syndrome(pSS)and investigate the correlation between MIF level and disease activity.Methods The pSS patients diagnosed in Beijing University of Chinese Medicine Third Affiliated Hospital(hereinafter referred to as"our hospital")from October 2009 to October 2018 were enrolled as pSS group(96 cases);the other age-and sex-matched healthy people were included as control group(70 people)during the same period of our hospital.The disease activity of patients with pSS were evaluated,and the salivary MIF level of each group were compared.The relationship between salivary MIF level and the incidence of pSS was evaluated,while the correlation between saliva MIF levels and EULAR Sjogren's syndrome disease activity index(ESSDAI)were analyzed.Results The salivary MIF level in the pSS group was significantly higher than that in the control group,and the differences were highly statistically significant(P<0.01).Salivary MIF level was the independent risk factors for pSS[OR(95%CI)=1.996(1.339-2.977),P<0.01].Salivary MIF level was positively correlated with ESSDAI(r=0.276,P<0.01).Conclusion Salivary MIF level is expected to be an important biomarkers for predicting the development of pSS.

关 键 词：原发性干燥综合征 巨噬细胞迁移抑制因子 唾液 生物标志物 

分 类 号：R781.4[医药卫生—口腔医学]