补肾健脾化痰法治疗遗忘型轻度认知损害的临床效果  

The clinical efficacy of invigorating the kidney, strengthening spleen and eliminating phlegm in the treatment of amnestic mild cognitive impairment

作　　者：吴冬月 魏明清 田金洲[2] 时晶[2] WU Dongyue;WEI Mingqing;TIAN Jinzhou;SHI Jing(Department of Traditional Chinese Medicine,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Ward 3,Department of Neurology,Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]首都医科大学附属北京友谊医院中医科,北京100050 [2]北京中医药大学附属东直门医院脑病三区,北京100700

出　　处：《中国医药导报》2019年第28期122-125,共4页China Medical Herald

基　　金：国家科技重大专项课题（2011ZX09302-006-01）

摘　　要：目的评价补肾健脾化痰法治疗遗忘型轻度认知损害(aMCI)临床效果。方法采用前瞻性、开放、空白对照的临床研究方法,将2014年1月~2017年1月就诊于北京中医药大学东直门医院脑病三区记忆门诊及周边社区具有认知功能下降主诉的患者进行初筛检查。筛选符合本研究诊断及纳入标准的aMCI患者共122例,根据随机数字表法将受试者分为两组:试验组(105例)口服补肾健脾化痰药物,对照组(17例)未使用任何改善认知水平药物或疗法。观察时间12周,记录治疗前后简易精神状态检查表(MMSE)评分及中医痴呆证候要素量表(PES-D/11)积分。结果总体认知评估方面,试验组治疗12周后MMSE总分高于治疗前,差异有统计学意义(P<0.05)。试验组MMSE总分明显高于对照组,差异有统计学意义(P<0.05)。中医证候方面,试验组治疗12周后肾虚、脾虚、痰浊积分低于治疗前,差异有统计学意义(P<0.05)。试验组治疗12周后肾虚、脾虚、痰浊积分均低于对照组,差异有统计学意义(P<0.05)。试验组不良反应共发生5例(6.4%),停药1周自行缓解,无严重不良事件。结论补肾健脾化痰法治疗aMCI 12周的疗效性及安全性较好,远期疗效需开展大样本、长疗程的临床试验进行验证。objective To evaluate the efficacy of invigorating the kidney,strengthening spleen and eliminating phlegm in the treatment of amnestic mild cognitive impairment(aMCI).Methods Using a prospective,open and blank-controlled clinical research method,patients admitted to Ward 3,the Department of Neurology of Dongzhimen Hospital of Beijing University of Chinese Medicine and surrounding communities with a cognitive decline function from January 2014 to January 2017 were screened.A total of 122 patients with aMCI were selected according to the diagnosis and inclusion criteria of this study.The subjects were divided into two groups by number table method:the experimental group(105 cases)received the drugs of invigorating the kidney,strengthening spleen and eliminating phlegm,while the control group(17 cases)was not used any medication or therapy to improves cognitive levels.The observation period was 12 weeks,while the mini mental state examination(MMSE)scores and the pattern element scale for dementia(PES-D/11)scores were recorded before and after treatment.Results In terms of overall cognitive assessment,the MMSE score after 12 weeks of treatment in the experimental group was higher than before treatment,and the difference was statistically significant(P<0.05).The MMSE score in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).In terms of Chinese medicine syndromes,the score of kidney deficiency,spleen deficiency and phlegm turbid syndrome in experimental group after 12 weeks of treatment were lower than before treatment,and the differences were statistically significant(P<0.05).The score of kidney deficiency,spleen deficiency and phlegm turbid syndromes in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were 5 cases(6.4%)of adverse reactions in experimental group,and the patients were relieved spontaneously for 1 week without serious adverse events.Conclusion The cur

关 键 词：遗忘型轻度认知功能损害 补肾健脾化痰法 中医证候 中药 

分 类 号：R749.1[医药卫生—神经病学与精神病学]