银杏叶片联合草酸艾司西酞普兰片治疗老年脑卒中后抑郁临床研究  

Clinical Study on Ginkgo Leaf Tablets Combined with Escitalopram Oxalate Tablets for Post-stroke Depression in the Senile

作　　者：王秀丽 陈红星 WANG Xiuli;CHEN Hongxing

机构地区：[1]衢州市第三医院老年科,浙江衢州324003 [2]衢州市中医医院肾内科,浙江衢州324000

出　　处：《新中医》2019年第11期95-98,共4页New Chinese Medicine

摘　　要：目的:观察银杏叶片联合草酸艾司西酞普兰片治疗老年脑卒中后抑郁(PSD)的临床疗效。方法:选择老年PSD患者80例,按随机数字表法分为研究组和对照组各40例。对照组给予银杏叶片口服治疗,研究组在对照组基础上给予草酸艾司西酞普兰片口服治疗,治疗时间均为8周。观察2组患者治疗前后汉密尔顿抑郁量表(HAMD)评分、日常生活能力量表(ADL)评分、美国国立卫生研究院卒中量表(NHISS)评分和白细胞介素(IL)-1、超敏C-反应蛋白(hs-CRP)、5-羟色胺(5-HT)的变化。比较2组患者临床疗效和不良反应发生情况。结果:研究组总有效率为97.50%,显著高于对照组82.50%(χ^2=5.000,P=0.025)。治疗前,2组NIHSS评分、HAMD评分、ADL评分比较,差异无统计学意义(P>0.05)。治疗后,2组NIHSS评分、HAMD评分、ADL评分均较治疗前降低,但研究组NIHSS评分、HAMD评分、ADL评分均低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组IL-1、hs-CRP、5-HT水平比较,差异无统计学意义(P>0.05)。治疗后,2组IL-1、hs-CRP水平较治疗前降低,5-HT水平较治疗前升高;且研究组IL-1、hs-CRP水平低于对照组,5-HT水平高于对照组;差异均有统计学意义(P<0.05)。研究组不良反应发生率为5.00%,显著低于对照组20.00%(χ^2=4.443,P=0.035)。结论:银杏叶片联合草酸艾司西酞普兰片治疗老年PSD的疗效显著,安全性高。Objective:To observe the clinical effect of ginkgo leaf tablets combined with escitalopram oxalate tablets for post-stroke depression(PSD) in the senile.Methods:A total of 80 cases of PSD senile patients were divided into the study group and the control group according to the random number table method,40 cases in each group.The control group was treated with oral administration of ginkgo leaf tablets,and the study group was additionally treated with oral administration of escitalopram oxalate tablets based on the treatment of the control group.Both groups were treated for eight weeks.Before and after treatment,the scores of Hamilton Depression Scale(HAMD),Activities of Daily Living Scale(ADL) as well as National Institute of Health Stroke Scale(NHISS),and the changes of interleukin-1(IL-1),high-sensitivity c-reactive protein(hs-CRP) and 5-hydroxytryptamine(5-HT) in the two groups were observed.The clinical effect and the incidence of adverse reactions in the two groups were compared.Results:The total effective rate was 97.50% in the study group,obviously higher than that of 82.50% in the control group(χ^2=5.000,P=0.025).Before treatment,compared the scores of NIHSS,HAMD and ADL in the two groups,there was no significance in the difference(P>0.05).After treatment,the scores of NIHSS,HAMD and ADL in the two groups were decreased when compared with those before treatment,but the scores of NIHSS,HAMD and ADL in the study group were lower than those in the control group,differences being significant(P<0.05).Before treatment,compared the levels of IL-1,hs-CRP and 5-HT in the two groups,there was no significance in the difference(P>0.05).After treatment,the levels of IL-1 and hs-CRP in the two groups were decreased when compared with those before treatment,while the level of 5-HT was increased when compared with that before treatment;the levels of IL-1 and hs-CRP in the study group were lower than those in the control group,while the level of 5-HT was higher than that in the control group;differences being significant

关 键 词：脑卒中后抑郁 草酸艾司西酞普兰片 银杏叶片 细胞因子 汉密尔顿抑郁量表(HAMD)评分 日常生活能力量表(ADL)评分 美国国立卫生研究院卒中量表(NHISS)评分 

分 类 号：R749.13[医药卫生—神经病学与精神病学]