八髎穴导气针法联合美沙拉嗪治疗活动期溃疡性结肠炎临床研究  

Clinical Study on Regulating qi Needling Method at Baliao Point Combined with Mesalazine for Ulcerative Colitis at Active Stage

作　　者：庞慧明 PANG Huiming

机构地区：[1]天台县人民医院肛肠外科

出　　处：《新中医》2019年第11期209-213,共5页New Chinese Medicine

摘　　要：目的:观察八髎穴导气针法联合美沙拉嗪治疗活动期溃疡性结肠炎的临床疗效。方法:将60例活动期溃疡性结肠炎患者按随机数字表法分为对照组和观察组各30例。对照组予美沙拉嗪肠溶片口服治疗,观察组在对照组基础上予八髎穴导气针法治疗。治疗前后评定2组主要临床症状评分、Baron评分,测定患者静脉血肿瘤坏死因子-α(TNF-α)、白细胞介素-6 (IL-6)、IL-8及IL-10水平。结果:观察组总有效率为96.67%,显著高于对照组70.00%,差异有统计学意义(χ^2=7.68,P<0.05)。治疗前,2组腹痛、腹泻、黏液脓血便症状积分比较,差异无统计学意义(P>0.05)。治疗后,2组腹痛、腹泻、黏液脓血便症状积分较治疗前降低,且观察组各项症状积分均低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组Baron评分比较,差异无统计学意义(P>0.05)。治疗后,2组Baron评分较治疗前明显降低(P<0.05);且观察组Baron评分明显低于对照组(P<0.05)。治疗前,2组血TNF-α、IL-6、IL-8、IL-10水平比较,差异无统计学意义(P>0.05)。治疗后,2组血TNF-α、IL-6、IL-8水平较治疗前降低,IL-10水平较治疗前升高;且观察组TNF-α、IL-6、IL-8水平明显低于对照组,IL-10水平高于对照组;差异均有统计学意义(P<0.05)。结论:八髎穴导气针法联合美沙拉嗪可明显缓解活动期溃疡性结肠炎患者的临床症状,改善肠道黏膜的炎症反应,这可能与其调节TNF-α、IL-6、IL-8、IL-10水平有关。Objective:To observe the clinical effect of the therapy of conductive air needling at Baliao point combined with mesalazine for ulcerative colitis at active stage.Methods:A total of 60 patients with ulcerative colitis at active stage were divided into the control group and the observation group according to the random number table,30 cases in each group.The control group was treated with mesalazine enteric-coated tablets orally,and the observation group was additionally treated with conductive air needling at Baliao point based on the treatment of the control group.Before and after treatment,the main clinical symptom scores and Baron scores in the two groups were assessed and the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL-8 and IL-10 of venous blood were measured.Results:The total effective rate was96.67% in the observation group,significantly higher than that of 70.00% in the control group,the difference being significant(χ^2=7.68,P<0.05).Before treatment,there was no significant difference being found in the comparison of the symptom scores of abdominal pain,diarrhea and mucus and bloody purulent stools in the two groups(P>0.05).After treatment,the symptom scores of abdominal pain,diarrhea and mucus and bloody purulent stools in the two groups were decreased when compared with those before treatment,and those in the observation group were lower than those in the control group,differences being significant(P<0.05).Before treatment,there was no significant difference in the comparison of Baron scores between the two groups(P>0.05).After treatment,Baron scores in both groups were significantly decreased when compared with those before treatment(P<0.05),and the score in the observation group was significantly lower than that in the control group(P<0.05).Before treatment,the levels of TNF-α,IL-6,IL-8 and IL-10 in the two groups showed no significant difference(P>0.05).After treatment,the levels of TNF-α,IL-6 and IL-8 in the two groups were decreased when compared with those before treatment

关 键 词：活动期溃疡性结肠炎 八髎穴 针刺 美沙拉嗪 Baron评分 炎症因子 

分 类 号：R574.62[医药卫生—消化系统] R246.1[医药卫生—内科学]