SLE患者血清抗β2GPⅠ抗体和ACL表达与其他实验室指标及临床并发症的相关分析  

The correlation analysis of the level of serum anti-β2GPⅠ antibodies and ACL with other laboratory index and clinical complications in SLE patients

作　　者：刘阳[1] LIU Yang(Clinical laboratory of Henan provincial people's hospital,Henan Zhengzhou 450003)

机构地区：[1]河南省人民医院检验科,河南郑州450003

出　　处：《医学检验与临床》2019年第9期1-3,共3页Medical Laboratory Science and Clinics

摘　　要：目的:研究抗β2GPⅠ抗体和ACL对SLE病人各实验室指标和一些临床并发症的影响。方法:对174例病人进行队列研究,将病人分为抗β2GPⅠ抗体组,ACL组和阴性对照组,分别收集病人的血小板、红细胞、血红蛋白、D-二聚体的含量,记录病人是否患有血栓症、肺动脉高压和心脏瓣膜疾病,然后对各组数据进行分析。结果:抗β2GPⅠ抗体组和ACL组病人的血小板、红胞、血红蛋白相比阴性对照组均显著降低(P<0.05),而D-二聚体显著升高(P<0.05)。抗β2GPI抗体组和AdL组病人的血栓症、肺动脉高压和心脏瓣膜病的发生率显著升高(P<0.05)。结论:SLE+抗β2GPⅠ抗体和ACL可引起血小板、红细胞、血红蛋白降低,D-二聚体升高,且可引起血栓症、肺动脉高压和心脏瓣膜病等并发症发病率升高。Objective:To estimate the effect of high serum an ti-β2GPⅠantibodies and ACL on other laboratory index and clinical complications in SLE patients.Methods:Cohort study in 174 patients was carried out laboratory index and Clinical evaluations were performed.Then the collected data was analyzed Results:The population with high level of serum anti-β2GPⅠand ACL has lower PLT,RBC,Hb and higher D-Dimer than control group(P<0.05).The cumulative incidence of thrombosis and pulmonary hypertension and heart valve disease in the group with high anti-β2GPⅠand ACL was significantly higher than control group(P<0.05).Conclusion:Low PLT and RBC and Hb and high D-D im er can exist in SLE patients with high serum anti-β2GPⅠ antibodies and ACL,besides,the high morbidity of thrombosis and pulmonary hypertension and heart valve disease can be observed in SLE patients with high serum anti-β2GPⅠantibodies and ACL.

关 键 词：抗β2GPl抗体 抗磷脂抗体 系统性红斑狼疮 

分 类 号：R[医药卫生]