泛素蛋白酶体途径的应用研究进展  

Research progress of the application of ubiquitin proteasome pathway

作　　者：董慧琳[1] 聂红明[1] 梅昭荷 赵彬彬 姜煜资 陈建杰[1] 王灵台[1] DONG Huilin;NIE Hongming;MEI Zhaohe;ZHAO Binbin;JIANG Yuzi;CHEN Jianjie;WANG Lingtai(Department of Hepatology,Shuguang Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shuguang Clinical Medical College,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院肝病科,上海201203 [2]上海中医药大学曙光临床医学院,上海201203

出　　处：《中国医药导报》2019年第29期25-30,共6页China Medical Herald

基　　金：国家自然科学基金资助项目（81001492、81373618）;上海中医药大学附属曙光医院四明科研项目

摘　　要：泛素蛋白酶体途径(UPP)是一种依赖ATP进行的,具有高度特异性和选择性的蛋白质降解途径,其在真核细胞中广泛存在,在细胞周期调控、信号转导、抗原提呈、免疫应答等生物学功能中发挥着重要作用。目前已知,该途径与神经退行性变、病毒感染、肿瘤、心血管等方面都有着密切联系,一旦UPP异常,影响α-synuclein、Parkin蛋白功能,就会导致帕金森病的发生。SCF蛋白复合物中Skp2、E3泛素连接酶c-Cbl、泛素结合酶E2C等均与肿瘤的发生发展有关。HCMV病毒等多种病毒都会攻击或利用UPP来逃避免疫攻击。此外,还有许多疾病的发生也均有报道与UPP有关,但目前我们对该体系知之甚少,对此的相关研究也远远不够,还需更多探索。The ubiquitin proteasome pathway which is dependent on ATP has a highly specific and selective protein degradation pathway.UPP exists in eukaryotic cells widely,and plays an important role in cell cycle regulation,signal transduction,antigen presentation,immune response and other biological functions.Currently,it is known that this pathway is closely related to neurodegeneration,viral infection,tumor,cardiovascular and other aspects.Once UPP abnormal affects the function of α-synuclein and Parkin protein,it will lead to Parkinson's disease.Skp2,E3 ubiquitin ligase c-cbl and ubiquitin ligase E2C in the SCF complex protein are all related to the development of tumors.Many viruses,such as the HCMV virus,can attack or use UPP to evade immune attacks.In addition,many diseases have also been reported to be related to UPP,but at present we know very little about the system,and the related research is far from enough,and more exploration is needed.

关 键 词：泛素蛋白酶体途径 神经退行性变 病毒感染 肿瘤 心血管 

分 类 号：R362[医药卫生—病理学]