前列腺癌组织中VEGF-C、Bcl-xl的mRNA表达及与临床病理特征及预后的关系  

mRNA expression of VEGF-C and Bcl-xl in prostatic carcinoma tissues and their correlation with clinical pathological characteristics and prognosis

作　　者：韩跃辅[1] 陈东 彭敛 黄洪才[1] HAN Yuefu;CHEN Dong;PENG Lian;HUANG Hongcai(The First District of Urinary Surgery,Yuebei People's Hospital,Guangdong Province,Shaoguan 512026,China)

机构地区：[1]广东省粤北人民医院泌尿外科一区

出　　处：《中国医药导报》2019年第29期96-99,103,共5页China Medical Herald

基　　金：广东省自然科学基金项目（2015A03031038）

摘　　要：目的研究前列腺癌(PCa)组织中血管内皮生长因子C(VEGF-C)mRNA与B细胞淋巴瘤/白血病-xl(Bcl-xl)mRNA的表达,分析两者表达与PCa患者临床病理特征及预后的相关性。方法收集2014年1月~2016年6月广东省粤北人民医院经手术获取的132例PCa组织及40例良性前列腺增生(BPH)组织,采用实时定量PCR法检测PCa组织及BPH组织中VEGF-C mRNA、Bcl-xl mRNA的表达,分析两者表达与临床病理特征关系;采用Kaplan-Meier生存分析探究不同VEGF-C mRNA、Bcl-xl mRNA表达与患者预后的关系。结果PCa组织中VEGF-C mRNA、Bcl-xl mRNA的相对表达量均显著高于BPH组织(均P<0.05)。VEGF-C mRNA与Bcl-xl mRNA的表达呈正相关(r=0.637,P<0.05)。不同年龄、Gleason评分、入院PSA的患者PCa组织中VEGF-C mRNA、Bcl-xl mRNA表达比较,差异均无统计学意义(均P>0.05)。不同TNM分期及是否存在远处转移的的患者PCa组织中VEGF-C mRNA、Bcl-xl mRNA表达比较,差异均有统计学意义(均P<0.05)。高表达VEGF-C mRNA、Bcl-xl mRNA患者3年总体生存率分别明显低于低表达VEGF-C、Bcl-xl患者(均P<0.05)。结论PCa组织中VEGF-C mRNA、Bcl-xl mRNA表达增高与肿瘤TNM分期和是否伴有远处转移有关,VEGF-C mRNA、Bcl-xl mRNA有可能成为新的PCa诊断和治疗的生物学靶点。Objective To study the expression of vascular endothelial growth factor C(VEGF-C)mRNA and B cell lymphoma/leukemia-xl(Bcl-xl)mRNA in prostatic carcinoma(PCa)tissues and analyze the correlation between their expressions and clinical pathological characteristics and prognosis of PCa patients.Methods One hundred and thirty-two cases of PCa and forty cases of benign prostatic hyperplasia(BPH)tissue obtained by surgery in Yuebei People's Hospital Guangdong Province from January 2014 to June 2016 were collected.Real-time quantitative PCR was used to detect the expressions of VEGF-C mRNA and Bcl-xl mRNA in PCa and BPH tissues,and the relationship between their expressions and clinical pathological characteristics was analyzed.Kaplan-meier survival analysis was used to explore the difference in prognosis of patients with different VEGF-C mRNA and Bcl-xl mRNA expressions.Results The relative expressions of VEGF-C mRNA and Bcl-xl mRNA in PCa tissues were significantly higher than those in BPH tissues(all P<0.05).The expression of VEGF-C mRNA was positively correlated with the expression of Bcl-xl mRNA(r=0.637,P<0.05).There was no significant difference in the expression of VEGF-C mRNA and Bcl-xl mRNA in PCa tissues of patients with different age,Gleason score and admission to PSA(all P>0.05).The expression of VEGF-C mRNA and Bcl-xl mRNA in PCa tissues of patients with different TNM stages and with or without distant metastasis was statistically significant(all P<0.05).The 3-year overall survival rate of patients with high expression of VEGF-C mRNA and Bcl-xl mRNA was significantly lower than that of patients with low expression of VEGF-C mRNA and Bcl-xl mRNA(all P<0.05).Conclusion The increased expression of VEGF-C mRNA and Bcl-xl mRNA in PCa tissue is related to the TNM stage of tumor and whether it is accompanied by distant metastasis.VEGF-C mRNA and Bcl-xl mRNA may become new biological targets for PCa diagnosis and treatment.

关 键 词：前列腺癌 VEGF-C BCL-XL 临床意义 

分 类 号：R737.25[医药卫生—肿瘤]