硬化性肺细胞瘤临床病理分析  

Clinicopathological Analysis of Sclerosing Pneumocytoma

作　　者：雷瑞雪[1] 郭梅[1] 苗兰芳[1] LEI Ruixue;GUO Mei;MIAO Lanfang(Department of Pathology,Anyang Tumor Hospital,Anyang 455000,China)

机构地区：[1]安阳市肿瘤医院病理中心

出　　处：《肿瘤基础与临床》2019年第4期311-314,共4页journal of basic and clinical oncology

摘　　要：目的探讨硬化性肺细胞瘤的临床病理特征,并总结其诊断及鉴别诊断方法。方法回顾性分析8例经病理确诊的硬化性肺细胞瘤患者的临床病理资料。结果8例硬化性肺细胞瘤患者均为女性,年龄27~61岁,平均年龄48岁,2例有咯血症状,其余6例均为体检时发现,组织学上含实性区、乳头状区、硬化区及血管瘤样区4种组织学结构,存在间质圆形细胞和表面立方上皮细胞2种细胞类型。免疫组化示:间质圆形细胞表达甲状腺转录因子1(TTF-1)、上皮膜抗原(EMA)、波形蛋白,立方上皮细胞表达TTF-1、EMA、广谱细胞角蛋白、细胞角蛋白7。8例患者随访至今,均健康存活、未见复发及转移。结论硬化性肺细胞瘤是一种少见的肺良性肿瘤,术前诊断较困难,组织学形态结合免疫组化有助于其诊断和鉴别诊断。Objective To investigate the clinicopathological characteristics,diagnosis and differential diagnosis of sclerosing pneumocytoma.Methods The clinicopathological data of 8 patients with sclerosing pneumocytoma were retrospectively analyzed.Results Eight patients were all female.The average age was 48 years old(ranged from 27 to 61 years old).Two patients had the symptom of coughing blood,the rest were founded by the physical examination.The tumor tissues were composed by solid area,papillary area,sclerotic area and hemangioma-like area.There were two types of tumor cells:epitheloid cells and oval cells.Immunohistochemical staining revealed that the epithelioid cells expressed thyroid transcription factor(TTF-1),epithelial membrance antigen(EMA),pan cytokeratin and cell keratin 7,while the oval cells expressed TTF-1,EMA and Vimentin.Eight patients were followed up,no recurrences and metastasis were observed.Conclusion Sclerosing pneumocytoma is a rare tumor and preoperative diagnosis is difficult.Histological section combined with immunohistochemistry is effective for diagnosis and differential diagnosis of sclerosing pneumocytoma.

关 键 词：肺肿瘤 硬化性肺细胞瘤 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤] R730.4[医药卫生—临床医学]