Rational Fabrication and Biomedical Application of Biomolecule-Conjugated AIEgens through Click Reaction  

作　　者：Qiming Yuan Yong Cheng Xiaoding Lou Fan Xia 

机构地区：[1]Engineering Research Center of Nano-Geomaterials of Ministry of Education,Faculty of Materials Science and Chemistry,China University of Geosciences,Wuhan,Hubei 430074,China [2]State Key Laboratory of Material Processing and Die&Mould Technology,School of Materials Science and Engineering,Huazhong University of Science and Technology,Wuhan,Hubei 430074,China [3]Zhejiang Institute,China University of Geosciences,Hangzhou,Zhejiang 311305,China【摘要】Contents

出　　处：《Chinese Journal of Chemistry》2019年第10期1072-1082,共11页中国化学（英文版）

基　　金：This work is supported by the National Natural Science Foundation of China(Nos.21525523,21722507,21574048,21874121);the National Basic Research Program of China(973 Program,No.2015CB932600);the National Key R&D Program of China(Nos.2017YFA020800,2016YFF0100800);the Natural Science Foundation of Zhejiang Province of China(No.LY18B050002).

摘　　要：Recently,the issue of cancer has attracted extensive attention.Early diagnosis and timely therapy are important for cancer treatment.And lots of advanced fluorescent probes have been applied to cancer theranostics.However,the further development of these probes is limited by the disadvantages of poor targeting,weak sensitivity and photobleaching.Fortunately,the emergence of biomolecule-conjugated fluorescent probes with aggregationinduced emission properties has taken innovative impetus to the cancer theranostics.This review summarizes the rational fabrication and biomedical applications of biomolecule-conjugated A1E luminogens(AIEgens)based on"click reaction"over the past decade.In the meantime,the challenges of biomolecule-conjugated AIEgens in the field of biomedicine are also discussed.

关 键 词：AIE DIAGNOSIS RATIONAL 

分 类 号：R73[医药卫生—肿瘤]