盐酸帕洛诺司琼对比格拉司琼在老年急性髓系白血病化疗相关恶心和呕吐的临床研究  

Clinical study of palonosetron hydrochloride versus granisetron on chemotherapy-related nausea and vomiting in elderly patients with acute myeloid leukemia

作　　者：秦玲[1] 邓会阳 刘珂[1] 王娜[1] 张艳芝 冯金彪 Qin Ling;Deng Huiyang;Liu Ke;Wang Na;Zhang Yanzhi;Feng Jinbiao(Department of Hematology,First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院河南科技大学第一附属医院血液内科

出　　处：《山西医药杂志》2019年第22期2738-2740,共3页Shanxi Medical Journal

摘　　要：目的比较盐酸帕洛诺司琼与格拉司琼在老年急性髓系白血病(AML)化疗相关恶心呕吐(CINV)反应治疗效果。方法将符合纳入标准的老年AML患者24例,按随机数字表法分为试验组和对照组,每组各12例,试验组采用盐酸帕洛诺司琼注射液预防呕吐,对照组使用格拉司琼治疗,观察2组患者化疗期间及化疗后第1~5天的恶心、呕吐、食欲以及全身情况。结果帕洛诺司琼对比格拉司琼预防化疗过程中及化疗后急性CINV控制有效率分别为92%和83%,在治疗后48 h迟发性CINV的有效率分别是92%和83%,2组间比较差异有统计学意义(P<0.05);盐酸帕洛诺司琼在迟发性呕吐分层缓解率高于格拉司琼,2种药物均有轻微疲乏、便秘、头晕、头痛等不良反应。结论在老年AML化疗中,帕洛诺司琼对于预防CINV的疗效优于格拉司琼,不良反应发生率低、程度轻。Objective To compare the therapeutic effects of palonosetron hydrochloride and granisetron in the treatment of nausea and vomiting(CINV)in elderly patients with acute myeloid leukemia(AML).Methods Twentyfour elderly patients with AML who met the inclusion criteria were randomly divided into the experimental group and the control group,12 in each group.The experimental group was treated with palonosetron hydrochloride injection to prevent vomiting,and the control group was treated with granisetron.We mainly observed the nausea,vomiting,appetite and general condition of the two groups of patients during chemotherapy and on the 1st to 5th day after chemotherapy.Results The effective rate of palonosetron versus granisetron in the prevention of chemotherapy and chemotherapy after acute CINV was 92%and 83%,respectively,and the effective rate of delayed CINV was 92%and 83%at 48 h after treatment,respectively.The difference was statistically significant(P<0.05);Palonosetron hydrochloride had a higher rate of delayed vomiting than granisetron,and both drugs had mild fatigue,constipation,dizziness,headache and other adverse reactions.Conclusion In elderly AML chemotherapy,palonosetron is superior to granisetron in preventing CINV,and the incidence of adverse reactions is low and mild.

关 键 词：急性髓系白血病 老年 帕洛诺司琼 格拉司琼 呕吐 恶心 药物疗法 

分 类 号：R73[医药卫生—肿瘤]