Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women  

作　　者：Meiqun Jia Lulu Ren Lingmin Hu Hongxia Ma Guangfu Jin Dake Li Ni Li Zhibin Hu Dong Hang 

机构地区：[1]Department of Epidemiology,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China [2]Department of Gynecologic Oncology,the Affiliated Tumor Hospital of Nantong University(Nantong Tumor Hospital),Nantong,Jiangsu 226361,China [3]Department of Reproduction,the Affiliated Changzhou Maternity and Child Health Care Hospital of Nanjing Medical University,Changzhou,Jiangsu 213003,China [4]Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Medicine,Nanjing Medical University,Nanjing 211166,China [5]Department of Gynecologic Oncology,Nanjing Maternity and Child Health Hospital,Nanjing,Jiangsu 210004,China [6]Program Office for Cancer Screening in Urban China,National Cancer Centre/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China [7]State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China

出　　处：《The Journal of Biomedical Research》2019年第5期308-316,共9页生物医学研究杂志（英文版）

基　　金：supported by National Natural Science Foundation of China(81502873);the Natural Science Foundation of Jiangsu Province(BK20150997);Priority Academic Program for the Development of Jiangsu Higher Education Institutions(Public Health and Preventive Medicine);Innovation Fund of State key Laboratory of Reproductive Medicine(SKLRMGC201802);Clinical Medicine Research Fund of the Chinese Medical Association(17020420711);Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(PPZY2015A067)

摘　　要：Long noncoding RNA(lncRNA) HOTAIR and MALAT1 are implicated in the development of multiple cancers. Genetic variants within HOTAIR and MALAT1 may affect the gene expression, thereby modifying genetic susceptibility to cervical cancer. A case-control study was designed, including 1 486 cervical cancer patients and 1 536 healthy controls. Based on RegulomeDB database, 11 SNPs were selected and genotyped by using Sequenom’s Mass ARRAY. Univariate and multivariate logistic regression models were used to calculate the odds ratio(OR) and 95% confidence interval(CI). We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer, while the C allele of rs1787666 in MALAT1 was associated with decreased risk. Compared to individuals with 0–1 unfavorable allele, those with 3–4 unfavorable alleles showed18% increased odds of having cervical cancer. Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility.Long noncoding RNA(lncRNA) HOTAIR and MALAT1 are implicated in the development of multiple cancers. Genetic variants within HOTAIR and MALAT1 may affect the gene expression, thereby modifying genetic susceptibility to cervical cancer. A case-control study was designed, including 1 486 cervical cancer patients and 1 536 healthy controls. Based on RegulomeDB database, 11 SNPs were selected and genotyped by using Sequenom’s Mass ARRAY. Univariate and multivariate logistic regression models were used to calculate the odds ratio(OR) and 95% confidence interval(CI). We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer, while the C allele of rs1787666 in MALAT1 was associated with decreased risk. Compared to individuals with 0–1 unfavorable allele, those with 3–4 unfavorable alleles showed18% increased odds of having cervical cancer. Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility.

关 键 词：CERVICAL cancer VARIANT long noncoding RNA HOTAIR MALAT1 

分 类 号：R73[医药卫生—肿瘤]