改良道家认知疗法对男性残留型精神分裂症患者阴性症状及认知功能改善作用的研究  

Improvement of negative symptoms and cognitive function through modified Taoist cognitive therapy in male residual schizophrenia patients

作　　者：陆如平 高慧[1] 彭红[1] 沈怡[1] 戴晶璟 顾燕[1] 陈剑华 LU Ruping;GAO Hui;PENG Hong(Shanghai No.1 Civil Mental Health Center,Shanghai 201105,China)

机构地区：[1]上海市民政第一精神卫生中心,上海市201105 [2]上海交通大学医学院附属精神卫生中心

出　　处：《精神医学杂志》2019年第2期86-91,共6页Journal of Psychiatry

基　　金：国家自然科学基金(编号:81501154,81871051)

摘　　要：目的探究改良道家认知疗法对于男性残留型精神分裂症患者阴性症状及认知功能改善作用。方法选取男性残留型精神分裂症患者119例,随机分为研究组(59例)和对照组(60例)。研究组在常规治疗的基础上给予为期8周的改良道家认知疗法。分别于治疗前及治疗后第4、8周末采用阳性和阴性综合征量表(PANSS)、自知力与治疗态度问卷(ITAQ)、个人和社会功能量表(PSP)及简易智力状态检查(MMSE)评定,同时检测血清人脑源性神经营养因子(BDNF)浓度。结果治疗后第4、8周末研究组PANSS总分及阴性症状、一般精神病理症状分量表评分均较治疗前降低(P<0.05),ITAQ总分、BDNF检测结果较治疗前升高(P<0.05);治疗后第8周末研究组PSP、MMSE评分较治疗前升高(P<0.05)。治疗后第4、8周末研究组PANSS总分及阴性症状、一般精神病理症状分量表评分均低于对照组(P<0.05),ITAQ总分、BDNF检测结果均高于对照组(P<0.05);治疗后第8周末研究组PSP、MMSE评分均高于对照组(P<0.05)。结论改良道家认知疗法能改善男性残留型精神分裂症患者的阴性症状及认知功能,提高社会功能及治疗依从性。Objective To explore the effect of modified Taoist cognitive therapy on negative symptoms and cognitive function in male residual schizophrenia patients.Methods A total of 119 male patients with residual schizophrenia were selected and randomly divided into study group(59 cases)treated with 8-week modified Taoist cognitive therapy combined with conventional therapy and control group(60 cases)treated only with conventional therapy.All subjects were assessed with Positive and Negative Syndrome Scale(PANSS),Insight and Treatment Attitude Questionnaire(ITAQ),Personal and Social Performance Scale(PSP)and Mini-Mental State Examination(MMSE),levels of serum brain-derived neurotrophic factor(BDNF)before treatment,and at the 4^th,8^th weekends after treatment.Results At the 4^th,8^th weekends after treatment,the total scores and factor scores of negative symptom,general psychopathological symptom of PANSS in study group decreased significantly compared with those before treatment(P<0.05);the total scores of ITAQ and levels of BDNF increased significantly compared with those before treatment(P<0.05).At the end of the 8^th week after treatment,the total scores of PSP and MMSE in study group increased significantly compared with those before treatment(P<0.05).At the 4^th,8^th weekends after treatment,the total scores and factor scores of negative symptom,general psychopathological symptom of PANSS in study group were all significantly lower than those in control group(P<0.05),and the total scores of ITAQ and levels of BDNF in study group were all significantly higher than those in control group(P<0.05).At the end of the 8^th week after treatment,the total scores of PSP and MMSE in study group were all significantly higher than those in control group(P<0.05).Conclusion Modified Taoist cognitive therapy can improve the negative symptoms and cognitive function in male residual schizophrenia patients,so as to improve their social function and treatment compliance.

关 键 词：残留型精神分裂症 改良道家认知疗法 阴性症状 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]