生物标志物在早期痛风肾病中的研究进展  

Research progress of biomarkers in early gouty nephropathy

作　　者：陈浩全 吴小珍 雷仲平 隆丽娜 袁科森 朱其生 Chen Haoquan;Wu Xiaozhen;Lei Zhongping;Long Lina;Yuan Kesen;Zhu Qisheng(Department of Laboratory Medicine,Yuli City Orthopaedics Hospital,Yulin 537000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]玉林市中西医结合骨科医院检验科

出　　处：《实用检验医师杂志》2019年第3期186-187,共2页Chinese Journal of Clinical Pathologist

基　　金：玉林市科学研究与技术开发计划项目(玉市科201912006)~~

摘　　要：痛风肾病(GN)起病隐匿,患者早期无明显症状及实验室异常表现,不易被察觉,许多病例确诊时已进入肾衰竭期。因此,寻找对早期肾损伤更敏感的生物标志物或检测手段,提高早期GN诊断敏感度和特异度,对治疗效果及患者预后进行监测和提早判断,可帮助临床更好地制定个体化治疗方案,对防止病情恶化至关重要。本文对GN早期诊断常用及潜在参与GN发病和病情进展的生物指标研究进展进行综述。Gouty nephropathy(GN)has a latent onset without obvious symptoms and laboratory manifestations in the early stage,resulting in difficulty in early detection,and many cases have already entered into renal failure stage when they are definitely diagnosed.Therefore,it is very important to look for more sensitive biomarkers or detection method for early renal injury to elevate the sensitivity and specificity of early GN diagnosis,that may help monitor the therapeutic effect and the patients'prognosis and the early dianosis can assist clinicians to formulate a more suitabe individualized therapeutic regime to prevent the deterioration of GN.This article reviews the research progress of biological indicators commonly used in early diagnosis of GN and potential involved in the pathogenesis and progress of GN.

关 键 词：痛风肾病 早期诊断 生物标志物 

分 类 号：R73[医药卫生—肿瘤]