加味臌消散治疗肝硬化失代偿期伴肝性腹胀临床研究  

Clinical Study of Using Modified Guxiao Powder in the Treatment of Decompensated Cirrhosis with Hepatic Abdominal Distension

作　　者：廖宇[1] 陈青竹 胡文艳[1] 张玮[1] 李泓町 赵迪加 LIAO Yu;CHEN Qingzhu;HU Wenyan(Traditional Chinese Medicine Hospital of Chongqing City(Chongqing 400021,China;Yubei Road Community Health Service Center of Shapingba District(Chongqing 400030,China)

机构地区：[1]重庆市中医院,重庆400021 [2]重庆市沙坪坝渝碚路社区卫生服务中心,重庆400030

出　　处：《四川中医》2019年第11期113-116,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：重庆市中医院内课题(编号:2014-2-33)

摘　　要：目的:观察加味臌消散穴位超声药物透入联合西医疗法治疗肝硬化失代偿期伴肝性腹胀的临床疗效以及对主要生化指标、临床症状改善的影响。方法:选取2016年9月~2017年9月本科室肝硬化失代偿期伴肝性腹胀住院患者60例作为研究对象。采用随机数表法分为甲、乙、丙三组,每组均为20人。三组均给予常规基础治疗,甲组20例增加加味臌消散,予超声药物透入治疗,选取中府、期门、中脘、天枢四个穴位,每次治疗时间为30分钟,一天治疗两次。乙组增加予四磨汤口服液口服,一次20ml,1天3次。丙组增加枸橼酸莫沙必利分散片口服,一次5mg,一天三次。三组均连续治疗7天为1疗程,1个疗程治疗结束后判断疗效。结果:甲组总有效率85%;乙组60%。丙组总有效率65%,三组好转率比较,甲组较乙、丙组差异有显著性意义(P<0.05)。三组治疗后ALT、AST、CHE、PA、TBil、CRE等生化指标水平较治疗前均有一定程度的改善。三组治疗后相互比较,生化指标改善程度方面均没有显著差异(P>0.05)。甲组治疗后腹胀程度、腹围测量、肠鸣音次数、腹部鼓音区面积、肝门排气次数等症状缓解程度评分方面与乙、丙组比较,差异有统计学意义(P<0.05)。结论:加味臌消散超声药物透入穴位联合西医疗法治疗肝性腹胀较单纯西医治疗,以及四磨汤口服液、莫沙必利有更好的疗效,且安全、可靠。加味臌消散超声药物透入穴位联合西药治疗不失为治疗肝性腹胀的可供选择方案。Objective:To observe the clinical effect of Modified Guxiao Powder acupoint ultrasound drug penetration combined with western medical treatment on decompensated cirrhosis with hepatic abdominal distention, and its influence on the improvement of main biochemical indexes and clinical symptoms. Methods:From September 2016 to September 2017, 60 patients with decompensated cirrhosis accompanied by hepatic abdominal distention were selected as the study subject. Random number table method was used to divide them into three groups:group A, group B and group C, each group consisted of 20 people. All the three groups were given routine basic treatment. In group A, 20 cases were treated with Modifed Guxiao Dispersion and ultrasound drug penetration. Four acupoints, Zhongfu, Qimen, Zhongwan and Tianshu, were selected. Each treatment lasted 30 minutes, twice a day. The group B was given Simo Decoction Oral Liquid orally, 20 ml at a time, three times a day. The group C was given Mosapride Citrate Dispersible Tablets orally, 5 mg once, three times a day. All the three groups were treated for 7 consecutive days as a course of treatment, and the curative effect was judged after the end of one course of treatment. Results:The total effective rate was 85% in the group A and 60% in the group B. The total effective rate of the group C was 65%. There was a significant difference between the group A and the group B(P<0.05). After treatment, the levels of ALT, AST, CHE, PA, TBil, CRE and other biochemical indicators in the three groups were improved to some extent. There was no significant difference in the improvement of biochemical indexes among the three groups after treatment(P>0.05). There were significant differences between the group A and the group B and C in the degree of abdominal distension, abdominal circumference measurement, number of bowel sounds, area of abdominal tympanic area and number of hepatic vent exhaust after treatment(P<0.05). Conclusion:Modified Guxiao Dissipative Ultrasound Drug Penetration into acupoints a

关 键 词：肝性腹胀 肝硬化失代偿期 加味臌消散 

分 类 号：R575.2[医药卫生—消化系统]