二聚环色胺生物碱的全合成研究进展  

Progress in Total Syntheses of Dimeric Cyclotryptamine Alkaloids

作　　者：沈先福 彭天凤 周永云[2] 奚永开 赵静峰[2] 羊晓东[2] 张洪彬[2] Shen Xianfu;PengTianfeng;Zhou Yongyun;Xi Yongkai;ZhaoJingfeng;YangXiaodong;ZhangHongbin(Center for Yunnan-Guizhou Plateau Chemical Functional Materials and Pollution Control,College of Biological Resource and Food Engineering,Qujing Normal University,Qujing 655011,Yunnan;Key Laboratory of Natural Products Transformation and Utilization in Yunnan Province,Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education and Yunnan Province,Kunming 650091)

机构地区：[1]曲靖师范学院云贵高原化学功能材料与污染治理研究中心生物资源与食品工程学院,云南曲靖655011 [2]云南大学云南省天然产物转化与利用及教育部自然资源药物化学重点实验室,昆明650091

出　　处：《有机化学》2019年第10期2685-2704,共20页Chinese Journal of Organic Chemistry

基　　金：长江学者和创新团队发展计划(No.IRT17R94);国家自然科学基金(Nos.2152197,21861032);云南省自然科学基金(Nos.2018FD078,2017FH001-020);曲靖师范学院(No.2018QN002)资助项目~~

摘　　要：二聚环色胺生物碱具有相邻的立体位阻较大的全碳季碳中心和良好的生物活性,作为合成目标一直吸引着合成化学家的广泛关注.立体选择地构建这类生物碱中相邻的全碳季碳中心是该类型分子化学合成的挑战.综述总结了二聚环色胺生物碱十二年来的全合成研究进展.As interesting synthetic targets,dimeric cyclotryptamine alkaloids bearing sterically hindered vicinal all-carbon quaternary stereocenters have attracted significant attention from the synthetic community.Stereocontrolled synthesis of the congested all-carbon quaternary stereocenters in these alkaloids presents a formidable challenge.This review summarizes the synthetic efforts towards dimeric cyclotryptamine alkaloids in the last twelve years.

关 键 词：二聚环色胺 生物碱 相邻季碳 氧化吲哚 全合成 

分 类 号：R28[医药卫生—中药学]