宫颈癌盆腔外照射经OPS引导提高摆位精确度临床研究  

Clinical study on the improvement of placement accuracy by OPS guided by pelvic external irradiation of cervical cancer

作　　者：赵迪[1] 秦亮[1] 邱腾[1] 张碧云[1] Zhao Di;Qin Liang;Qiu Teng;Zhang Biyun(Department of Radiotherapy,Jiangsu Provincial Hospital of Chinese Medicine,Jiangsu Nanjing 210029,China.)

机构地区：[1]江苏省中医院放射治疗科

出　　处：《现代肿瘤医学》2019年第23期4251-4255,共5页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81301971);江苏省中医院博士基金(编号:Y16010)

摘　　要：目的:探讨宫颈癌盆腔外照射治疗中OPS系统应用价值。方法:选取61例宫颈癌患者,随机分为实验组、对照组,实验组使用OPS辅助CBCT验证,对照组仅使用CBCT验证。CBCT采集治疗前图像信息,匹配实时摆位图像与定位图像,分析比较两组X、Y、Z三轴误差数据,对放疗中及放疗后所致不良反应及疗效进行临床比较分析。结果:实验组摆位误差X(2.9±0.8)mm、Y(3.9±1.1)mm、Z(2.0±0.9)mm小于对照组误差X(4.3±1.4)mm、Y(5.9±1.7)mm、Z(3.2±1.5)mm。实验组骨髓抑制、急性肠道症状等可观测不良反应大于Ⅰ级的患者数明显少于对照组。实验组在X、Y、Z三个方向上的值分别是4.03 mm、5.45 mm、3.65 mm;对照组在X、Y、Z三个方向上值分别是6.51 mm、8.38 mm、5.49 mm(P<0.05)。结论:在宫颈癌放疗摆位中引入OPS可有效提高摆位精确度,降低摆位误差;在不降低治疗疗效情况下,有效减轻了放疗期间不良反应。Objective:To evalute the application value of OPS system in the treatment of cervical cancer with pelvic radiation.Methods:A total of 61 patients with cervical cancer were randomly divided into treatment group and control group.The experimental group was confirmed by OPS-assisted CBCT,and the control group was only verified by CBCT.CBCT collected pre-treatment image information,matched real-time placement images localization images.The three sets of X,Y,and Z triaxial error data were andysed,and the adverse reactions and therapeutic effects caused by radiotherapy and radiotherapy were compared.Results:The placement error X(2.9±0.8)mm,Y(3.9±1.1)mm,Z(2.0±0.9)mm of treatment group were less than the error of control group X(4.3±1.4)mm,Y(5.9±1.7)mm,Z(3.2±1.5)mm.The number of patients with observable side effects greater than grade Ⅰ in myelosuppression and acute intestinal mucosa was significantly less in the treatment group than in the control group.The values of the treatment group in the three directions of X,Y,and Z were 4.03 mm,5.45 mm,and 3.65 mm,respectively.The values of the control group in the three directions of X,Y,and Z were 6.51 mm,8.38 mm,and 5.49 mm,respectively(P<0.05).Conclusion:The introduction of OPS in the radiation therapy placement can effectively improve the positioning accuracy and reduce the placement error.Side effects during radiotherapy are effectively alleviated without reducing the therapeutic effect.

关 键 词：宫颈癌 放射治疗 OPS 摆位误差 

分 类 号：R737.33[医药卫生—肿瘤]