STAT1和STAT3在脑胶质瘤中作用的研究进展与展望  

Research progress and prospect of the roles of STAT1 and STAT3 in glioma

作　　者：胡新龙 林超 鞠海涛[1] 万方[2] 窦长武[1] Hu Xinlong;Lin Chao;Ju Haitao;Wan Fang;Dou Changwu(Department of Neurosurgery,Inner Mongolia Medical University Affiliated Hospital,Inner Mongolia Hohhot 010050,China;Inner Mongolia Agricultural University,Inner Mongolia Hohhot 010050,China.)

机构地区：[1]内蒙古医科大学附属医院神经外科,内蒙古呼和浩特010050 [2]内蒙古农业大学,内蒙古呼和浩特010050

出　　处：《现代肿瘤医学》2019年第23期4315-4319,共5页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81660509)

摘　　要：脑胶质瘤是常见的中枢神经系统肿瘤,约占颅内肿瘤半数以上。信号转导与转录激活因子(signal transducer and activator of transcription,STAT)是一种信号传导和转录活化因子蛋白,可以从各个角度调节细胞的生长、分化、存活和凋亡。STAT1目前被普遍认为是一种肿瘤抑制因子,而STAT3目前被定义为致癌基因。本文就STAT1和STAT3在脑胶质瘤发生发展中的作用及其潜在的交叉调控机制进行阐述,并期望共表达质粒STAT3-siRNA-STAT1可能为脑胶质瘤的治疗提供新思路。Glioma is the most common central nervous system tumors,accounting for more than half of intracranial tumors.Signal transducer and activator of transcription(STAT) is family of signaling and transcriptional activator proteins that regulates cell growth,differentiation,survival and apoptosis.STAT1 is currently widely recognized as a tumor suppressor gene,and STAT3 is currently defined as an oncogene.This article reviews the roles of STAT1 and STAT3 played in the development of glioma and their integrated effects and mechanisms,and discusses the co-expression of STAT3-siRNA and STAT1’s potential as a novel glioma treatment.

关 键 词：STAT1基因 STAT3基因 脑胶质瘤 

分 类 号：R739.41[医药卫生—肿瘤]