Recent advances in radical-mediated [2+2+m] annulation of 1,n-enynes  

作　　者：Chong-Hui Xu Yang Li Jin-Heng Li Jian-Nan Xiang Wei Deng 

机构地区：[1]State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China [2]Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle,Nanchang Hangkong University,Nanchang 330063,China

出　　处：《Science China Chemistry》2019年第11期1463-1475,共13页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21625203,21871126);the Jiangxi Province Science and Technology Project(20182BCB22007)

摘　　要：1,n-Enynes are a versatile class of unsaturated hydrocarbons that found broad applications in the synthetic community of natural products,biologically active structures and functional materials.Typical methods for the transformations of 1,n-enynes include the radical-mediated[2+2+m]annulation reaction as they are particularly efficient accesses to functionalized polycyclic compounds.We herein highlighted recent process in the radical-mediated[2+2+m]annulation of 1,n-enynes,including[2+2+1]and[2+2+2]modes,for the construction of five-to six-membered-ring-fused polycyclic scaffolds.Meanwhile,the mechanisms for these transformations were described.1,n-Enynes are a versatile class of unsaturated hydrocarbons that found broad applications in the synthetic community of natural products, biologically active structures and functional materials. Typical methods for the transformations of 1,n-enynes include the radical-mediated [2+2+m] annulation reaction as they are particularly efficient accesses to functionalized polycyclic compounds. We herein highlighted recent process in the radical-mediated [2+2+m] annulation of 1,n-enynes, including [2+2+1] and[2+2+2] modes, for the construction of five-to six-membered-ring-fused polycyclic scaffolds. Meanwhile, the mechanisms for these transformations were described.

关 键 词：RADICAL ANNULATION OXIDANTS 1 n-enynes POLYCYCLES 

分 类 号：O64[理学—物理化学]