Iodine（Ⅲ） reagent（ABX–N3）-induced intermolecular anti-Markovnikov hydroazidation of unactivated alkenes  

作　　者：Xiaonan Li Pinhong Chen Guosheng Liu 

机构地区：[1]State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences, Chinese Academy of Sciences

出　　处：《Science China Chemistry》2019年第11期1537-1541,共5页中国科学（化学英文版）

基　　金：supported by the National Basic Research Program of China(973-2015CB856600);the National Natural Science Foundation of China(21532009,21821002,21790330,21761142010);the Science and Technology Commission of Shanghai Municipality(17XD1404500,17QA1405200,17JC1401200);the strategic Priority Research Program(XDB20000000);the Key Research Program of Frontier Science(QYZDJSSW-SLH055)of the Chinese Academy of Sciences

摘　　要：Anti-Markovnikov hydroazidation of unactivated alkenes using ABX–N3 as an initiator has been developed at room temperature,wherein hydrogen azide(HN3)acts as both hydrogen and azidating agent.Notably,the HN3 reagent was generated from azidotrimethylsilane(TMSN3)and acetic acid in situ.The reaction itself displays broad substrate scope,good yields and excellent regioselectivities.Anti-Markovnikov hydroazidation of unactivated alkenes using ABX–N3 as an initiator has been developed at room temperature,wherein hydrogen azide（HN3） acts as both hydrogen and azidating agent. Notably, the HN3 reagent was generated from azidotrimethylsilane（TMSN3） and acetic acid in situ. The reaction itself displays broad substrate scope, good yields and excellent regioselectivities.

关 键 词：ANTI-MARKOVNIKOV hydroazidation iodine(Ⅲ) reagent(ABX–N3) unactivated alkenes 

分 类 号：O62[理学—有机化学]