18例上消化道癌前病变患者舌苔与土壤真菌相关性分析  

The analysis of the relationship between the fungal microbiota from soil and tongue coating of 18 patients with precancerous lesions of upper gastrointestinal

作　　者：华召来[1] 孙娴 王晨怡 陆斌[3] 徐硕 向春婕 张军峰[2] 魏文强 Hua Zhaolai;Sun Xian;Wang Chenyi;Lu Bin;Xu Shuo;Xiang Chunjie;Zhang Junfeng;Wei Wenqiang(Yangzhong Cancer Institute,People′s Hospital of Yangzhong City,Yangzhong 212200,China;Medical School,Nanjing University of Chinese Medicine,Nanjing 210023,China;Department of oncology,People′s Hospital of Yangzhong City,Yangzhong 212200,China;Cancer Registry Office,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]江苏省扬中市人民医院肿瘤防治研究所,212200 [2]南京中医药大学医学院,210023 [3]扬中市人民医院肿瘤科,212200 [4]国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院肿瘤登记办公室,北京100021

出　　处：《中华预防医学杂志》2019年第11期1166-1169,共4页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(81473458,81473593);国家重点研发计划(2016YFC0901404);镇江市重点研发社会发展项目(SHW2016024);镇江市卫生计生科技重点专项(SHW2017025)。

摘　　要：对18例上消化道癌前病变患者的舌苔和其自留地土壤真菌测序,进行菌群α、β多样性及菌群结构分析,并采用Spearman秩相关分析两者之间的相关性.上消化道癌癌前病变(PLUG)患者舌苔真菌丰富度指数(1.67±2.79)、多样性指数(0.25±0.10)均低于自留地土壤的真菌丰富度指数(4.00±4.69)和多样性指数(0.99±0.18)(P值均<0.001);PLUG患者舌苔中11个真菌分类单元的相对丰度与土壤存在正相关(P值均<0.05).The fungal microbiota from self-retained soil and tongue coating of 18 patients with precancerous lesions of upper gastrointestinal (PLUG) were sequenced. The diversity of α, β in and the structure of the microbial community were analyzed, and the association of them was quantified by using the Spearman rank correlation method. The richness index (1.67±2.79) and the diversity index (0.25±0.10) of the fungal microbiota from tongue coating of PLUG patients were significantly lower than those from soil (4.00± 4.69;0.99±0.18) (all P values<0.001). The relative abundance of 11 taxa from tongue coating of these PLUG patients was positively associated with that from soil (all P values<0.05).

关 键 词：癌前状态 舌 土壤 真菌 病例对照研究 

分 类 号：R[医药卫生]