β-葡聚糖与模式识别受体Dectin-1相互作用研究进展  

The progress of interaction between β-glucan and pattern recognition receptor Dectin-1

作　　者：宿凡 管培竹 杨金波 管华诗[1] 于广利[1] 赵晨阳 SU Fan;GUAN Pei-zhu;YANG Jin-bo;GUAN Hua-shi;YU Guang-li;ZHAO Chen-yang(School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;School of Life Science,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]中国海洋大学医药学院,山东青岛266003 [2]兰州大学生命科学学院,甘肃兰州730000

出　　处：《中国海洋药物》2019年第5期54-60,共7页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金-山东省海洋科学中心项目（U1606403）资助

摘　　要：β-葡聚糖是自然界资源最丰富的多糖之一,尤其真菌来源的β-1,3-葡聚糖是结构独特、免疫调节活性好且研究报道最多的葡聚糖。本文对β-葡聚糖的发现、化学结构与生物活性、以及β-1,3-葡聚糖作为病原相关分子模式(PAMP)与其模式识别受体(PRR)Dectin-1之间的相互作用进行了综述,着重论述了不同理化性质的β-葡聚糖对人和鼠来源Dectin-1不同亚型的激活作用,所得结论为以Dectin-1为靶点抗肿瘤药物的研发提供了参考。β-glucan is the most abundant polysaccharide in the natural resource,especially the fungi β-1,3-glucans,which has unique structure and has been extensively reported for its immune modulatory activities.We summarized the discovery of β-1,3-glucan,its chemical structure and bioactivity,the interactions between β-glucan as a pathogen-associated molecular pattern(PAMP)with its pattern recognition receptor(PRR)Dectin-1,with the emphasis on the activation of different β-glucans on human or mouse Dectin-1 different isoforms.The conclusions obtained provide the references for the research and development of anti-tumor drugs targeting Dectin-1.

关 键 词：Β-葡聚糖 结构与活性 病原相关分子模式(PAMP) 模式识别受体(PRR) DECTIN-1 

分 类 号：R965[医药卫生—药理学]