Dynamic modifications of biomacromolecules: mechanism and chemical interventions  

作　　者：Chu Wang Peng Zou Caiguang Yang Lei Liu Liang Cheng Xiaopeng He Liang Zhang Yan Zhang Hualiang Jiang Peng RChen 

机构地区：[1]College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China [2]Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [3]Department of Chemistry,Tsinghua University,Beijing 100084,China [4]Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China [5]School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China [6]Department of Pharmacology and Chemical Biology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [7]National Natural Science Foundation of China,Beijing 100085,China

出　　处：《Science China(Life Sciences)》2019年第11期1459-1471,共13页中国科学（生命科学英文版）

摘　　要：Biological macromolecules(proteins,nucleic acids,polysaccharides,etc.)are the building blocks of life,which constantly undergo chemical modifications that are often reversible and spatial-temporally regulated.These dynamic properties of chemical modifications play fundamental roles in physiological processes as well as pathological changes of living systems.The Major Research Project(MRP)funded by the National Natural Science Foundation of China(NSFC)—"Dynamic modifications of biomacromolecules:mechanism and chemical interventions"aims to integrate cross-disciplinary approaches at the interface of chemistry,life sciences,medicine,mathematics,material science and information science with the following goals:(i)developing specific labeling techniques and detection methods for dynamic chemical modifications of biomacromolecules,(ii)analyzing the molecular mechanisms and functional relationships of dynamic chemical modifications of biomacromolecules,and(iii)exploring biomacromolecules and small molecule probes as potential drug targets and lead compounds.Biological macromolecules(proteins, nucleic acids, polysaccharides, etc.) are the building blocks of life, which constantly undergo chemical modifications that are often reversible and spatial-temporally regulated. These dynamic properties of chemical modifications play fundamental roles in physiological processes as well as pathological changes of living systems. The Major Research Project(MRP) funded by the National Natural Science Foundation of China(NSFC)—"Dynamic modifications of biomacromolecules: mechanism and chemical interventions" aims to integrate cross-disciplinary approaches at the interface of chemistry, life sciences, medicine, mathematics, material science and information science with the following goals:(i) developing specific labeling techniques and detection methods for dynamic chemical modifications of biomacromolecules,(ii)analyzing the molecular mechanisms and functional relationships of dynamic chemical modifications of biomacromolecules, and(iii) exploring biomacromolecules and small molecule probes as potential drug targets and lead compounds.

关 键 词：CHEMICAL BIOLOGY BIOMACROMOLECULE dynamic MODIFICATION MODIFICATION analysis CHEMICAL INTERVENTION 

分 类 号：F42[经济管理—产业经济]