BIOMACROMOLECULE

作品数：10被引量：45H指数：3
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Respiratory delivered vaccines:Current status and perspectives in rational formulation design
《Acta Pharmaceutica Sinica B》2024年第12期5132-5160,共29页Lan Wu Wenwen Xu Huiyang Jiang Mingshi Yang Dongmei Cun 
supported by the Liaoning Pan Deng Xue Zhe Scholar(No.XLYC2002061,China);the National Natural Science Foundation of China(No.82173768);the Overseas Expertise Introduction Project for Discipline Innovation(“111 Project”)(No.D20029,China);D.C.acknowledges financial support from the Science and Technology Foundation of Liaoning Province(NO.2022-MS-241,China);the Ministry of Education Chunhui Program(2020);L.W.acknowledges the financial support from the National Natural Science Foundation of China(No.82204316);the China Postdoctoral Science Foundation(No.2021TQ0219 and 2022MD713776,China).
The respiratory tract is susceptible to various infections and can be affected by many serious diseases.Vaccination is one of the most promising ways that prevent infectious diseases and treatment of some diseases suc...
关键词：Respiratory vaccines Respiratory drug delivery strategies Mucosal immunity Biomacromolecule delivery systems Inhaled formulation Particle engineering Nucleic acid Lung deposition 
A comprehensive review on surface modifications of black phosphorus using biological macromolecules
《Frontiers of Materials Science》2024年第2期37-59,共23页Chaiqiong Guo Xuhong He Xuanyu Liu Yuhui Wang Yan Wei Ziwei Liang Di Huang 
supported by the National Natural Science Foundation of China(Grant Nos.12272253,82103147,12202302,31800684,and 11802197);the Natural Science Foundation of Shanxi Province,China(Grant Nos.202203021221047,20210302124007,and 20210302124405);the Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2021SX-AT008 and 2021SX-AT009);the Central Guidance on Local Science and Technology Development Fund of Shanxi Province(YDZJSX2021A021);The Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province(20220006)is also acknowledged with gratitude.
Black phosphorus(BP),a novel two dimensional material,exhibits remarkable photoelectric characteristics,ultrahigh photothermal conversion efficiency,substantial specific surface area,high carrier mobility,and tunable ...
关键词：blackphosphorus tumor therapy BIOCOMPATIBILITY surface modification BIOMACROMOLECULE 
Milk-derived exosomes as a promising vehicle for oral delivery of hydrophilic biomacromolecule drugs被引量：3
《Asian Journal of Pharmaceutical Sciences》2023年第2期137-149,共13页Yuting Li Liyun Xing Lingling Wang Xi Liu Licheng Wu Mingjie Ni Zhou Zhou Lian Li Xiuxiu Liu Yuan Huang 
The authors gratefully acknowledge financial support from National Natural Science Foundation of China(81872818);National Key R&D Program of China(2021YFE0115200).
Exosomes,as promising vehicles,have been widely used in the research of oral drug delivery,but the generally low drug loading efficiency of exosomes seriously limits its application and transformation.In this study,we...
关键词：Milk-derived exosomes Loading efficiency Drug lipophilicity Molecular weight Drug release Oral delivery 
Quantitatively relating magnetic resonance T_(1)and T_(2)to glycosaminoglycan and collagen concentrations mediated by penetrated contrast agents and biomacromolecule-bound water被引量：1
《Regenerative Biomaterials》2023年第1期871-888,共18页Jingming Gao Xian Xu Xiaoye Yu Ye Fu Hongjie Zhang Siyi Gu Dinglingge Cao Quanyi Guo Liming Xu Jiandong Ding 
supported by National Natural Science Foundation of China(grant no.52130302).W。
Magnetic resonance imaging(MRI)is a promising non-invasive method to assess cartilage regeneration based on the quantitative relationship between MRI features and concentrations of the major components in the extracel...
关键词：magnetic resonance imaging COLLAGEN GLYCOSAMINOGLYCAN bound water CARTILAGE 
Release of deposited MnO2 nanoparticles from aqueous surfaces
《Journal of Environmental Sciences》2020年第4期234-243,共10页Hainan Wang Ruixing Huang Chengxue Ma Xiaoling Li Caihong Liu Qiang He Zhengsong Wu Jun Ma Xiaoliu Huangfu 
financially supported by the National Natural Science Foundation of China(Nos.51878092,51608067);the Scientific and Technological Innovation Special Program of Social Livelihood of Chongqing(No.cstc2015shmsztzx0053);the Fundamental Research Funds for the Central Universities(No.2019CDXYCH0026)
Changes in solution chemistry and transport conditions can lead to the release of deposited MnO2 nanoparticles from a solid interface,allowing them to re-enter the aqueous environment.Understanding the release behavio...
关键词：QCM-D Release kinetics MnO2 nanoparticles(MnO2 NPs) Solution pH BIOMACROMOLECULE 
Dynamic modifications of biomacromolecules: mechanism and chemical interventions被引量：3
《Science China(Life Sciences)》2019年第11期1459-1471,共13页Chu Wang Peng Zou Caiguang Yang Lei Liu Liang Cheng Xiaopeng He Liang Zhang Yan Zhang Hualiang Jiang Peng RChen 
Biological macromolecules(proteins,nucleic acids,polysaccharides,etc.)are the building blocks of life,which constantly undergo chemical modifications that are often reversible and spatial-temporally regulated.These dy...
关键词：CHEMICAL BIOLOGY BIOMACROMOLECULE dynamic MODIFICATION MODIFICATION analysis CHEMICAL INTERVENTION 
Biomacromolecules as carriers in drug delivery and tissue engineering被引量：37
《Acta Pharmaceutica Sinica B》2018年第1期34-50,共17页Yujie Zhang Tao Sun Chen Jiang 
Natural biomacromolecules have attracted increased attention as carriers in biomedicine in recent years because of their inherent biochemical and biophysical properties including renewability,nontoxicity, biocompatibi...
关键词：BIOMACROMOLECULE PROTEIN POLYSACCHARIDE Drug delivery Tissue engineering 
Biocompatibility and Antibacterial Effects of 6-Deoxy-6-Aminoethyleneamino Cellulose
《Journal of Biosciences and Medicines》2018年第1期51-62,共12页Susanne Finger Michael Zieger Cornelia Wiegand Tim Liebert Thomas Heinze Peter Elsner Uta-Christina Hipler 
Recently, there is a need of alternatives to antibiotics due to increasing antibiotic-resistant microorganism. Promising classes of bioactive polymers are 6-deoxy-6-amino cellulose derivatives. The purpose of the stud...
关键词：6-Deoxy-6-Aminoethyleneamino Celluloses ANTIBACTERIAL BACTERIA BIOCOMPATIBILITY BIOMACROMOLECULE KERATINOCYTE 
Theoretical model of biomacromolecule through nanopore including effects of electrolyte and excluded volume
《Applied Mathematics and Mechanics(English Edition)》2016年第6期787-802,共16页Chibin ZHANG Xiaohui LIN Hao YANG 
supported by the National Natural Science Foundation of China(No.51375090)
A theoretical model for the translocation process of biomacromolecule is developed based on the self-consistent field theory （SCFT）, where the biomacromolecule is regarded as a self-avoiding polymer chain actuated b...
关键词：polymer through nanopore electrolyte effect excluded volume effect freeenergy conformation entropy 
Effects of high-energy-pulse-electron beam radiation on biomacromolecules被引量：1
《Science China Chemistry》2008年第1期86-91,共6页ZHU Hong XU JingZao LI ShiQiang SUN XiaoYu YAO SiDe WANG ShiLong 
Supported by the National Natural Science Foundation of China (Grant Nos. 30570376 and 50673078);the Shanghai Key Fundamental Project (Grant No. 06JC14068);the Innovation Program of Shanghai Municipal Education Commis-sion (Grant No. 08ZZ21)
To study the molecular mechanism of high mutation frequency induced by high-energy-pulse-electron (HEPE) beam radiation, the effects of HEPE radiation on yeast cells, plasma membrane, plasmid DNA, and protein activity...
关键词：high-energy-pulse-electron beam BIOMACROMOLECULE radiation DAMAGE 
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