Surface-adaptive nanoparticles with near-infrared aggregation-induced emission for image-guided tumor resection  

作　　者：Xiaoyan Zhang Cong Li Wenyi Liu Hanlin Ou Dan Ding 

机构地区：[1]Key Laboratory of Bioactive Materials,Ministry of Education,College of Life Sciences,Nankai University,Tianjin 300071,China [2]Tianjin Stomatological Hospital,Hospital of Stomatology,Medical College,Nankai University,Tianjin 300041,China [3]Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy,Cancer Institute,Xuzhou Medical University,Xuzhou 221002,China

出　　处：《Science China(Life Sciences)》2019年第11期1472-1480,共9页中国科学（生命科学英文版）

基　　金：supported by the NSFC (51622305 and 51873092);the National Basic Research Program of China (2015CB856503);the Fundamental Research Funds for the Central Universities, Nankai University (63191521, 63171218, and 63191176)

摘　　要：Aggregation-induced emission(AIE)nanoparticles(NPs)are widely used for image-guided tumor resection because of their high signal-to-noise ratios and long systemic circulation time.These NPs are derived by encapsulating small-molecule fluorescent dyes with AIE property inside the cores of NPs assembled by amphiphilic polymers.Although the systemic circulation of AIE NPs is prolonged,hydrophilic polymer coatings simultaneously decrease the binding and uptake of AIE NPs by tumor cells.To overcome this problem,surface-adaptive AIE dye-encapsulated mixed-shell micelles(MSMs)with polyethylene glycol/poly(β-amino ester)(PEG/PAE)surfaces were prepared.Due to the charge conversion ability of PAE,MSMs demonstrated enhanced cellular uptake by tumor cells in acidic conditions.In addition,compared with single-PEG-shelled micelles(PEGSMs),MSMs exhibited prolonged systemic circulation due to the presence of micro-phase separated surfaces.Moreover,due to the coordination effect of enhanced cancer cell uptake and prolonged systemic circulation time,MSMs were more enriched than PEGSMs in the tumor cells and exhibited excellent performance during image-guided tumor resection.Aggregation-induced emission(AIE) nanoparticles(NPs) are widely used for image-guided tumor resection because of their high signal-to-noise ratios and long systemic circulation time. These NPs are derived by encapsulating small-molecule fluorescent dyes with AIE property inside the cores of NPs assembled by amphiphilic polymers. Although the systemic circulation of AIE NPs is prolonged, hydrophilic polymer coatings simultaneously decrease the binding and uptake of AIE NPs by tumor cells.To overcome this problem, surface-adaptive AIE dye-encapsulated mixed-shell micelles(MSMs) with polyethylene glycol/poly(β-amino ester)(PEG/PAE) surfaces were prepared. Due to the charge conversion ability of PAE, MSMs demonstrated enhanced cellular uptake by tumor cells in acidic conditions. In addition, compared with single-PEG-shelled micelles(PEGSMs), MSMs exhibited prolonged systemic circulation due to the presence of micro-phase separated surfaces. Moreover, due to the coordination effect of enhanced cancer cell uptake and prolonged systemic circulation time, MSMs were more enriched than PEGSMs in the tumor cells and exhibited excellent performance during image-guided tumor resection.

关 键 词：aggregation-induced emission surface-adaptive enhanced cellular UPTAKE IMAGE-GUIDED tumor RESECTION 

分 类 号：R73[医药卫生—肿瘤]