不同剂量氨磺必利维持治疗对恢复期精神分裂症患者疗效、社会功能及生活质量的影响  

Effects of maintenance therapy with different doses of amisulpride on efficacy,social function,and quality of life of patients with convalescent schizophrenia

作　　者：韩毅[1] 左津淮[1] 安旭光[1] 刘远 Han Yi;Zuo Jinhuai;An Xuguang;Liu Yuan(Seventh Department of General Psychiatry,Tianjin Anding Hospital,Tianjin 300222,China)

机构地区：[1]天津市安定医院普通精神科(七科),300222

出　　处：《国际医药卫生导报》2019年第21期3593-3595,共3页International Medicine and Health Guidance News

摘　　要：目的观察不同剂量氨磺必利对精神分裂症患者恢复期的社会功能以及生活质量的影响.方法将本院2015年11月至2018年1月收治的60例精神分裂症患者随机分为对照组和观察组,每组30例.对照组给予半剂量氨磺必利治疗;观察组给予全剂量氨磺必利治疗.通过社会功能缺陷筛选量表评价患者社会功能,生活质量问卷得分评价患者生活质量,治疗有效率评价疗效.对比两组指标差异.结果治疗前,对照组SDSS评分(12.59±2.89)分,观察组(12.60±2.92)分,差异无统计学意义(t=0.333,P=0.982);治疗后,观察组SDSS评分为(3.98±0.98)分,显著低于对照组,差异有统计学意义(t=17.125,P=0.003).治疗后,观察组躯体功能、心理功能、社会功能、物质生活状态评分分别为(67.56±7.65)分、(71.45±7.48)分、(52.74±5.78)、分(64.28±7.35)分,均显著高于对照组,差异有统计学意义(t=16.244、18.387、20.872、19.873,均P<0.05).干预后,观察组有效率高达93.33%,显著高于对照组的66.67%,差异有统计学意义(P<0.05).结论全剂量氨磺必利能够提高精神分裂患者的生活质量,弥补社会功能缺陷.Objective To observe the effects of different doses of amisulpride on the social function and quality of life of patients with schizophrenia during recovery.Methods Sixty patients with schizophrenia admitted to our hospital between November,2015 and January,2018 were randomly divided into a control group and an observation group,with 30 cases in each group.The control group were given half dose of amisulpride,and the observation group full dose.The social function was evaluated by the social function defect screening scale.The quality of life questionnaire score was used to evaluate the patients'quality of life.And the treatment efficacy was evaluated.The indicators were compared between the two groups.Results Before the treatment,the SDSS score was(12.59±2.89)in the control group,and(12.60±2.92)in the observation group(t=0.333,P=0.982).After the treatment,the SDSS score of the observation group was(3.98±0.98),which was significantly lower than that of the control group(t=17.125,P=0.003).After the treatment,the scores of physical function,psychological function,social function,and material life status of the observation group were(67.56±7.65),(71.45±7.48),(52.74±5.78),and(64.28±7.35),which were significantly higher than those of the control group(t=16.244,18.387,20.872,and 19.873;all P<0.05).After the intervention,the effective rate of the observation group was 93.33%,and that of the control group 66.67%(P<0.05).Conclusions A full dose of amisulpride can improve the quality of life of patients with schizophrenia and compensate for social deficiencies.

关 键 词：氨磺必利 恢复期精神分裂症 社会功能 生活质量 

分 类 号：R74[医药卫生—神经病学与精神病学]