探讨LncRNA遗传多态性及其与结直肠癌风险和预后的相关性  

Explore the Genetic Polymorphism of Lncrna and Its Correlation with the Risk and Prognosis of Colorectal Cancer

作　　者：周春燕 黄可可[1] 任妹[1] 刘剑荣 夏洪娇[1] ZHOU Chunyan;HUANG Keke;REN Mei;LIU Jianrong;XIA Hongjiao(Pingxiang People’s Hospital,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市人民医院

出　　处：《中国医学创新》2019年第32期161-164,共4页Medical Innovation of China

基　　金：江西省卫生卫计委科技计划课题（20177200）

摘　　要：目的:探究并分析Lnc RNA遗传多态性与结直肠癌风险和预后的相关性。方法:选取2012年1月-2016年1月本院收治的结直肠癌患者123例,对其进行LncRNA遗传多态性检测,并探究其与结直肠癌发病及预后的相关性。此外,根据患者基因检测结果从中选取50例Loc285194基因高表达患者作为观察组,50例Loc285194低表达为对照组。观察并记录所有患者一般资料,分析结直肠癌预后影响因素与预后的相关性,比较两组术后并发症发生情况、患者生存情况。结果:对123例结直肠癌预后影响因素进行单因素分析,可见年龄、手术时间、rs6983267(GG)、Loc285194与结直肠癌的预后有关(P<0.05)。根据多因素分析结果,可见手术时间、rs6983267(GG)、Loc285194与结直肠癌的预后有关(P<0.05),其中手术时间、Loc285194与患者预后有较高相关性(P<0.05),而rs6983267(GG)与结直肠癌预后相关性稍低(P<0.05)。观察组患者吻合口漏/感染、性功能障碍、复发或者转移、粘连性肠梗阻、排尿功能障碍发生率均明显低于对照组(P<0.05)。对照组术后6个月、1年、3年的生存率分别为84.0%、64.0%、42.0%,观察组患者术后6个月、1年、3年分别为90.0%、82.0%、70.0%,观察组患者术后1、3年生存率均显著高于对照组(P<0.05)。结论:手术时间、rs6983267(GG)、Loc285194与结直肠癌的预后有关,其中Loc285194基因高表达的结直肠癌患者预后及术后并发症发生情况显著优于Loc285194基因低表达的患者,值得临床关注。Objective: To explore and analyze the relationship between Lncrna genetic polymorphism and colorectal cancer risk and prognosis. Method: From January 2012 to January 2016, 123 patients with colorectal cancer were selected to detect the genetic polymorphism of Lncrna, and its correlation with the incidence and prognosis of colorectal cancer was explored. In addition, 50 patients with high expression of Loc285194 gene were selected as the observation group and 50 patients with low expression of Loc285194 gene were selected as the control group according to the results of gene detection. The general data of all patients were observed and recorded. The correlation between prognosis factors and prognosis of colorectal cancer of all patients were analyzed. The occurrence of postoperative complications and the survival of two groups were compared. Result: Single factor analysis showed that age, operation time, rs6983267(GG), Loc285194 were related to the prognosis of colorectal cancer(P<0.05). According to the results of multi factor analysis, operation time, rs6983267(GG), Loc285194 were related to the prognosis of colorectal cancer(P<0.05). Among them, the operative time and Loc285194 had a higher correlation with prognosis(P<0.05), while rs6983267(GG) had a lower correlation with prognosis of colorectal cancer(P<0.05).The patients in the observation group had significantly lower incidence of anastomotic leakage/infection, sexual dysfunction, recurrence or metastasis, adhesive intestinal obstruction and urination dysfunction than those in the control group(P<0.05). After operation 6 months, 1 year and 3 years, the survival rate of the control group was respectively 84.0%, 64.0% and 42.0%, in the observation group, 90.0%, 82.0% and 70.0% respectively. The 1 year and three-year survival rate in the observation group were significantly higher than those of the control group(P<0.05). Conclusion: The operation time, rs6983267(GG) and Loc285194 are related to the prognosis of colorectal cancer. The prognosis and postoperati

关 键 词：基因型 结直肠癌 预后 

分 类 号：R73[医药卫生—肿瘤]