腹腔镜下CME术对结肠癌患者肿瘤标志物的影响  

Influence of Laparoscopic CME on Tumor Markers in Patients with Colon Cancer

作　　者：李勇 王涛[2] LI Yong;WANG Tao(Department of General Surgery,Wuhan Asia General Hospital,Wuhan 430056,China;Department of General Surgery,Yichang First People's Hospital,Yichang 443001,China)

机构地区：[1]武汉亚心总医院普外科,湖北武汉430056 [2]宜昌市第一人民医院普外科,湖北宜昌443001

出　　处：《临床医学工程》2019年第11期1467-1468,共2页Clinical Medicine & Engineering

摘　　要：目的探讨腹腔镜下CME术对结肠癌患者肿瘤标志物的影响。方法选取2015年1月至2019年1月收治的94例结肠癌患者,按照手术方式分为观察组和对照组各47例。观察组采用腹腔镜下CME术,对照组采用常规开腹手术。比较两组患者的手术指标和肿瘤标志物表达水平。结果观察组的手术出血量、肛门排气时间、术后引流液量、住院天数明显少于对照组(P<0.05)。术后3 d,两组患者的VEGF、 CCSA-2、 SICAM-1表达水平均明显高于术前,观察组的VEGF、 CCSA-2、 SICAM-1表达水平均明显低于对照组(P均<0.05)。结论采用腹腔镜下CME术能够有效改善结肠癌患者的临床治疗效果,降低肿瘤标志物的表达水平。Objective To explore the influence of laparoscopic CME on tumor markers in patients with colon cancer. Methods 94 patients with colon cancer from January 2015 to January 2019 were selected and divided into observation group and control group according to the operation methods, with 47 cases in each group. The observation group was given laparoscopic CME, and the control group received routine laparotomy. The surgical indicators and the expression levels of tumor markers were compared between the two groups. Results The operation blood loss, anal exhaust time, postoperative drainage volume and hospitalization days of the observation group were significantly less or fewer than those of the control group(P <0.05). 3 d after operation, the expression levels of VEGF, CCSA-2 and SICAM-1 in the two groups were significantly higher than those before operation, and the expression levels of VEGF, CCSA-2 and SICAM-1 in the observation group were significantly lower than those in the control group(all P <0.05). Conclusions Laparoscopic CME can effectively improve the clinical efficacy of patients with colon cancer, and reduce the expression levels of tumor markers.

关 键 词：腹腔镜 CME术 结肠癌 肿瘤标志物 

分 类 号：R735.3[医药卫生—肿瘤]