有机小分子催化α，β-不饱和酮的不对称共轭加成反应研究进展  

Asymmetric Conjugate Addition Reaction of α,β-Unsaturated Ketones by Organic Catalyst

作　　者：蒋伟健 陈志卫[1] JIANG Wei-jian;CHEN Zhi-wei(College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China)

机构地区：[1]浙江工业大学药学院

出　　处：《浙江化工》2019年第11期23-27,共5页Zhejiang Chemical Industry

摘　　要：α,β-不饱和酮的不对称共轭加成反应在有机合成中是一类连接C-C键的非常重要的反应。相比过渡金属催化,有机小分子催化剂有着独特的优势,如不含过渡金属、容易制备、价格低廉、反应条件温和以及稳定性强等。文章综述了几类有机小分子催化剂对α,β-不饱和酮的不对称共轭加成反应。结果表明,手性胺和手性磷酸催化剂在不对称加成中具有良好的收率及选择性,但是包含联萘酚骨架的催化剂对于大部分的共轭加成反应均具有优秀的催化作用以及优异的选择性。The asymmetric conjugate addition reaction ofα,β-unsaturated ketones is a very important reaction in the organic synthesis for linking C-C bonds.Compared with transition metal catalysts,organic-catalysts have unique advantages such as no metal residue,easy preparation,low price,mild reaction conditions and high stability.The asymmetric conjugate additionof several chiral organic catalysts toα,β-unsaturated ketoneswerereviewedfor.The results showed thatchiral amines and chiral phosphonic acid catalysts have good yields and selectivities in asymmetric conjugate addition,but the catalyst containing the binaphthol skeleton has highyields and excellent selectivities for most of the conjugate addition reactions.

关 键 词：Α Β-不饱和酮 手性催化剂 不对称共轭加成 

分 类 号：O62[理学—有机化学]