肾活检9825例临床病理分析  

Clinical pathological analysis of 9825 cases of renal biopsy

作　　者：房爱菊 杨香山 程凤凤 张晓莹 甄军晖 FANG Ai-ju;YANG Xiang-shan;CHENG Feng-feng;ZHANG Xiao-ying;ZHEN Jun-hui(Department of Pathology,Shandong Provincial Third Hospital,Jinan 250031,China)

机构地区：[1]山东省立第三医院病理科,济南250031 [2]济南齐鲁医学检验所病理科,济南250031 [3]山东大学齐鲁医院病理科,济南250012

出　　处：《临床肾脏病杂志》2019年第11期825-828,共4页Journal Of Clinical Nephrology

基　　金：山东省重点研发计划(NO.2018GSF121040)

摘　　要：目的探讨山东地区肾穿刺活检患者病理类型的分布特点以及疾病谱的变迁。方法收集2014年1月至2018年10月共计9825例肾活检患者的临床病理资料,对本地区肾脏疾病的临床病理特征进行回顾性分析。结果9825例病例中男女比例为1.22∶1,发病高峰年龄为40~60岁。其中原发性肾小球疾病7524例,占所有病例的76.58%,常见的病理类型依次为膜性肾病(53.08%),IgA肾病(25.23%)和微小病变性肾小球肾炎(15.47%),膜性肾病构成比呈逐渐增加趋势。在继发性肾病中,最常见为狼疮肾炎(21.08%);其次为糖尿病肾病(18.70%)和高血压肾损伤(17.26%)。结论本地区肾脏疾病多见于中年人,以原发性肾小球疾病最常见,其中膜性肾病和IgA肾病是最多见的病理类型,膜性肾病的检出明显高于全国其他地区,且有增高趋势。继发性肾小球疾病以狼疮肾炎、糖尿病肾病及高血压肾损伤为常见。Objective To investigate distribution characteristic and disease spectrum changes of the pathological typesin patients with renal puncture biopsy in Shandong.Methods The clinical pathological data of 9825 cases of renal biopsy from January 2014 to October 2018 were collected and analyzed retrospectively.Results The ratio of male to female was 1.22∶1 in 9825 cases.The peak age of theincidence was 40~60 years old.There were 7524 cases of primary glomerulonephropathy(PGN),accounting for 76.58%of all cases.The common pathological types were membranous nephropathy(MN,53.08%),IgA nephropathy(IgAN,25.23%)and minimal change glomerulonephritis(MCN,15.47%).Theconstituent ratio of membranous nephropathy increased gradually.Lupus nephritis(LN,21.08%)was the most common secondary nephropathy(SGN),followed by diabetic nephropathy(DN,18.70%)and hypertensive renal injury(HN,17.26%).Conclusions Renal diseases in this region are mostly common in middle-aged people,and primary glomerular diseases are the most common.MN and IgAN are the most common pathological types.The incidence of MN is significantly higher than that in other parts of the China and has an increasing trend.For SGN,LN is the most frequent types,followed by DN and HN.

关 键 词：肾组织活检 病理类型 膜性肾病 

分 类 号：R[医药卫生]