不同厂家利巴韦林片在不同溶出介质中溶出曲线比较  

Comparative Research on Dissolution Profiles of Ribavirin Tablets from Different Pharmaceutical Manufacturers in 4 Dissolving Mediums

作　　者：黄励坚 李湘[2] HUANG Li-jian;LI Xiang(Guangdong Zhaoqing Xinghu Biotechnology Co.,Ltd,Guangdong Zhaoqing 526040;School of Environmental and Chemical Engineering,Zhaoqing University,Guangdong Zhaoqing 526040,China)

机构地区：[1]广东肇庆星湖生物科技股份有限公司,广东肇庆526040 [2]肇庆学院环境与化工学院,广东肇庆526040

出　　处：《广州化工》2019年第21期105-106,122,共3页GuangZhou Chemical Industry

摘　　要：采用中国药典2015版四部通则0931第二法浆法,以磷酸缓冲液(p H为6.8)、醋酸缓冲液(p H 4.0)、盐酸溶液(p H 1.2)和水等4种溶液为溶出介质,搅拌转速为50 rpm,比较已上市利巴韦林片、自制片与进口利巴韦林片在4种不同的溶出介质中的溶出曲线,为评价药品质量提供依据。结果表明:自制利巴韦林片在4种溶出介质中15 min溶出度与国内、国外两种市售利巴韦林片相当,均大于85%。The method 2 in the general rule 0931 of the Chinese pharmacopoeia VolⅣ(2015 edition)was adapt to compare the dissolution profiles of ribavirin tablets of 3 different pharmaceutical manufacturers in 4 dissolution mediums(phosphate buffer,acetic acid buffer,hydrochloric acid solution and water)with a agitation speed of 50 rpm respectively to provide evidence for evaluating the quality of drugs.The results showed the dissolution rate of ribavirin tablets of each manufacturer in 4 dissolving mediums within 15 min was more than 85%.

关 键 词：利巴韦林片 溶出曲线 高效液相色谱 

分 类 号：R917[医药卫生—药物分析学]