LncRNAs在卵巢癌诊断和预后评估研究中的进展  

Research Progress on LncRNAs in the Diagnosis and Prognosis Evaluation of Ovarian Cancer

作　　者：张春兰[1] 贺红英[1] 韦露薇[1] 翟艳芝 廖婷[1] ZHANG Chun-Ian;HE Hong-ying;WEI Lu-wei;ZHAI Yan-zhi;LIAO Ting(The Fourth Affiliated Hospital of Guangxi Medical University,Liuzhou 545000,China)

机构地区：[1]广西医科大学第四附属医院

出　　处：《中国肿瘤》2019年第11期852-860,共9页China Cancer

摘　　要：近期,越来越多的研究关注长链非编码RNA(LncRNAs)对卵巢癌发展的关键调控作用。在卵巢癌组织及细胞中常常能检测到LncRNAs的失调,且失调的LncRNAs可极大地促进卵巢癌恶性表型的变化。该文阐述LncRNAs对卵巢癌细胞增殖、凋亡、细胞周期、迁移、侵袭、转移和耐药性等细胞活动的作用及影响机制,讨论LncRNAs在卵巢癌诊断和预后评估中的价值,建议LncRNAs可作为卵巢癌诊断及预后评估的潜在生物标志物,也是卵巢癌治疗的潜在靶点。Recently,many studies have focused on the key regulatory effects of long-chain noncoding RNAs(LncRNAs)on the development of ovarian cancer.Dysregulation of LncRNAs is often detected in ovarian cancer tissues and cells,which can greatly promote the expression of malignant phenotype.Based on recent research,this article describes the effects and mechanisms of LncRNAs on cell proliferation,apoptosis,cell cycle,migration,invasion,metastasis and drug resistance of ovarian cancer,and discusses the values of LncRNAs in the diagnosis and prognosis of ovarian cancer,suggests that LncRNAs may be used as potential biomarkers for diagnosis and prognosis assessment of ovarian cancer and as potential targets for ovarian cancer therapy.

关 键 词：LncRNAs 卵巢癌 细胞增殖 细胞凋亡 转移 诊断 预后 

分 类 号：R737.31[医药卫生—肿瘤]