自黏性软聚硅酮薄膜敷料用于防治放射性皮肤损伤效果的Meta分析  

Meta-analysis of self-adhesive soft silicone film dressings on preventing and treating radioactive skin lesion

作　　者：诸晓璇 郑美春[2] 覃惠英[3] Zhu Xiaoxuan;Zheng Meichun;Qin Huiying(School of Nursing,Sun Yat-Sen University,Guangzhou 510080,China;Department of Colorectum,Sun Yat-Sen University Cancer Center,Guangzhou 510060,China;Department of Nursing,Sun Yat-Sen University Cancer Center,Guangzhou 510060,China)

机构地区：[1]中山大学护理学院,广州510080 [2]中山大学肿瘤防治中心结直肠科,广州510060 [3]中山大学肿瘤防治中心护理部,广州510060

出　　处：《中华现代护理杂志》2019年第31期3997-4002,共6页Chinese Journal of Modern Nursing

摘　　要：目的 系统评价自黏性软聚硅酮薄膜敷料用于防治放射性皮肤损伤的效果.方法 计算机检索PubMed、Web of Science、Cochrane Library、Embase、CNKI、中文科技期刊数据库(VIP)及万方数据库中关于自黏性软聚硅酮薄膜敷料用于防治放射性皮肤损伤的随机对照试验(RCT),对符合纳入标准的研究运用RevMan 5.3软件进行Meta分析.结果 共纳入10篇RCTs,样本量共1 231例.Meta分析显示,自黏性软聚硅酮薄膜敷料可以降低Ⅱ级以上放射性皮炎的发生率(OR=0.14,95%CI 0.08~0.25, P<0.01);缩短放射野内皮肤放射性皮炎的出现时间(OR=0.07,95%CI 0.02~0.32,P<0.01);降低放射性皮炎主、客观症状评分(放射性皮肤损伤评估量表评分)(MD=-3.33,95%CI -5.96^-0.70,P<0.05).结论 放疗期间采用自黏性软聚硅酮薄膜敷料贴敷于放疗照射野内的皮肤表面可以降低放射性皮炎严重程度,缩短放射野内皮肤放射性损伤的出现时间,有效改善患者放射野皮肤的各种不适感以及放射治疗引起的皮肤反应对日常活动的影响程度.Objective To systematically assess the effects of self-adhesive soft silicone film dressings on preventing and treating radioactive skin lesion. Methods Randomized controlled trials (RCT) about self-adhesive soft silicone film dressings on preventing and treating radioactive skin lesion were retrieved from PubMed, Web of Science, Cochrane Library, Embase, CNKI, VIP and Wanfang databases, and RevMan 5.3 was used for Meta-analysis of the trials which met the inclusion criteria. Results Totally 10 RCTs were included, with a sample size of 1 231 cases. Meta-analysis revealed that self-adhesive soft silicone film dressings could reducethe incidence of GradeⅡ or above radiodermatitis (OR=0.14,95%CI 0.08-0.25,P< 0.01), shorten the occurrence time of radiodermatitis within the field of radiotherapy (OR=0.07,95%CI 0.02-0.32, P< 0.01), and reduce subjective and objective symptom scores of radiodermatitis (Radiation-induced Skin Reaction Assessment Scale, RISRAS) (MD=-3.33,95%CI-5.96--0.70,P< 0.05). Conclusions Self-adhesive soft silicone film dressings applied on the cutaneous surface within the field of radiotherapy can reduce the severity of radiodermatitis, shorten the occurrence time of radioactive skin lesion within the field of radiotherapy, and effectively ameliorate cutaneous discomfort within the field of radiotherapy and the effects of radiotherapy-induced skin reaction on daily activities.

关 键 词：放射性皮炎 自黏性软聚硅酮薄膜敷料 皮肤损伤 恶性肿瘤 META分析 

分 类 号：R73[医药卫生—肿瘤]