高压氧辅治对颅内动脉瘤栓塞术后神经功能缺损及脑动脉血流速度的影响  

Effect of Hyperbaric Oxygenation on Neurological Deficit and Cerebral Arterial Blood Flow Velocity after Intracranial Aneurysm Embolization

作　　者：丁文谦 张波 张震宇[2] DING Wenqian;ZHANG Bo;ZHANG Zhenyu(Pingxiang City Ping Mine General Hospital,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市萍矿总医院,江西萍乡337000 [2]江西省赣州市人民医院

出　　处：《中国医学创新》2019年第33期120-123,共4页Medical Innovation of China

基　　金：赣州市指导性科技计划项目(GZ2011ZSF211)

摘　　要：目的:观察高压氧辅治对颅内动脉瘤栓塞术后神经功能缺损及脑动脉血流速度的影响。方法:回顾性分析2017年6月-2019年5月在本院治疗的82例颅内动脉瘤栓塞术后患者的临床资料,依据治疗方法的不同将其分为对照组(盐酸法舒地尔治疗,n=39)和观察组(盐酸法舒地尔、高压氧联合治疗,n=43)。观察两组神经功能缺损(NFD)评分、大脑中动脉(MCA)血流速度、格拉斯哥预后量表(GOS)评分、脑血管痉挛(CVS)及不良反应。结果:两组治疗前NFD评分、MCA血流速度对比,差异均无统计学意义(P>0.05);观察组治疗后NFD评分、MCA血流速度均低于对照组,差异均有统计学意义(P<0.05);观察组预后良好比例高于对照组,CVS发生率低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论:颅内动脉瘤栓塞术患者接受高压氧辅治有利于降低CVS,改善神经功能及脑动脉血流速度,降低致残、致死风险。Objective:To observe the effect of hyperbaric oxygenation on neurological deficit and cerebral arterial blood flow velocity after intracranial aneurysm embolization.Method:The clinical data of 82 patients with intracranial aneurysm embolization treated in our hospital from June 2017 to May 2019 were retrospectively analyzed.According to the different treatment methods,they were divided into the control group(Fasudil Hydrochloride,n=39)and the observation group(Fasudil Hydrochloride combined with hyperbaric oxygenation,n=43).The neurological deficit(NFD)score,middle cerebral artery(MCA)blood flow velocity,Glasgow Outcome Scale(GOS)score,cerebral vasospasm(CVS)and adverse reactions of two groups were observed.Result:There were no significant differences in the NFD score and MCA blood flow velocity between the two groups before treatment(P>0.05).After treatment,the NFD score and MCA blood flow velocity in the observation group were lower than those in the control group(P<0.05).The prognosis of the observation group was higher than that of the control group,and the incidence of CVS was lower than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Hyperbaric oxygenation in patients with intracranial aneurysm embolization is beneficial to reduce CVS,improve neurological function and cerebral arterial blood flow velocity,and reduce the risk of disability and death.

关 键 词：颅内动脉瘤栓塞术 高压氧 盐酸法舒地尔 神经功能缺损 脑动脉血流速度 

分 类 号：R74[医药卫生—神经病学与精神病学]