GDM孕妇维生素D、血脂水平分析及相关性研究  

Analysis of the Levels of Vitamin D and Blood Lipid in Pregnant Women with GDM and Their Correlation

作　　者：翟庆娜[1] 刘芹兰[1] 袁康凯[1] 路瑞静 张修发[1] 王丰[1] ZHAI Qingna;LIU Qinlan;YUAN Kangkai;LU Ruijing;ZHANG Xiufa;WANG Feng(Maternal and Child Health Hospital in Baoan District of Shenzhen City,Shenzhen 518102,China)

机构地区：[1]广东省深圳市宝安区妇幼保健院

出　　处：《中国医学创新》2019年第33期142-145,共4页Medical Innovation of China

基　　金：深圳市宝安区科技计划项目(2016cx237)

摘　　要：目的:探讨妊娠期糖尿病(GDM)孕妇维生素D、血脂水平分析及相关性。方法:2017年1月-2019年1月在本院诊治的GDM孕妇中选取215例作为研究组,同期选取正常孕妇100例作为对照组。在孕24~28周检测血清维生素D、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白水平,对比两组维生素D、血脂水平,并以Logistic逐步回归分析法检验GDM孕妇维生素D、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白在GDM发病中的作用,并应用Pearson相关法分析血脂指标和维生素D之间的相关性。结果:研究组维生素D、高密度脂蛋白水平均低于对照组,总胆固醇、甘油三酯、低密度脂蛋白水平均高于对照组,差异均有统计学意义(P<0.05);经Logistic逐步回归分析可知:GDM发生的危险因素为总胆固醇(OR=1.152,P=0.004)、甘油三酯(OR=1.551,P=0.000),而保护性因素为维生素D(OR=0.993,P=0.047)、高密度脂蛋白(OR=0.318,P=0.000);经Pearson相关法分析:GDM孕妇体内维生素D与甘油三酯、高密度脂蛋白、低密度脂蛋白间无明显相关性(r=0.067、0.214、0.215、0.028,P>0.05)。结论:妊娠中期血清维生素D、血脂水平紊乱是GDM发生的重要因素,其中总胆固醇、甘油三酯为危险因素,维生素D和高密度脂蛋白为保护性因素。Objective:To investigate the levels of vitamin D and blood lipid in pregnant women with gestational diabetes mellitus(GDM)and their correlation.Method:From January 2017 to January 2019,215 GDM pregnant women were selected as the study group and 100 normal pregnant women as the control group.The serum levels of vitamin D,total cholesterol,triglyceride,high-density lipoprotein and low-density lipoprotein were measured at 24-28 weeks of gestation.The levels of vitamin D and lipid were compared between the two groups.The role of vitamin D,total cholesterol,triglyceride,high-density lipoprotein and low-density lipoprotein in the pathogenesis of GDM was examined by Logistic stepwise regression analysis.Pearson correlation analysis was used to analyze the correlation between blood lipid and vitamin D.Result:The level of vitamin D and high density lipoprotein in the study group were lower than those in the control group,and the levels of total cholesterol,triglyceride and low density lipoprotein were higher than those in the control group,the differences were statistically signifiicant(P<0.05).According to the Logistic stepwise regression analysis,the risk factors of GDM were total cholesterol(OR=1.152,P=0.004),triglyceride(OR=1.551,P=0.000),and the protective factors were vitamin D(OR=0.993,P=0.047),high density lipoprotein(OR=0.318,P=0.000).Pearson correlation analysis showed that there were no significant correlations between vitamin D and triglyceride,high density lipoprotein and low density lipoprotein in pregnant women with GDM(r=0.067,0.214,0.215,0.028,P>0.05).Conclusion:The disorder of serum vitamin D and blood lipid levels in the second trimester of pregnancy is an important factor in the occurrence of GDM,total cholesterol and triglyceride are risk factors,while vitamin D and high density lipoprotein are protective factors.

关 键 词：维生素 D 血脂 高密度脂蛋白 甘油三酯 总胆固醇 妊娠期糖尿病 相关性 

分 类 号：R[医药卫生]