新辅助化疗结合放疗与单纯放疗治疗局部晚期宫颈癌的效果比较  

Neoadjuvant Chemotherapy Combined with Radiotherapy and Radiotherapy Alone in the Treatment of Locally Advanced Cervical Cancer

作　　者：江燕[1] 黄雪芳[1] 林远雄[1] 郑碧华[1] 廖妮虹[1] JIANG Yan;HUANG Xuefang;LIN Yuanxiong;ZHENG Bihua;LIAO Nihong(Guangdong Agricultural Reclamation Center Hospital,Zhanjiang 524002,China)

机构地区：[1]广东省农垦中心医院

出　　处：《中国医学创新》2019年第31期38-41,共4页Medical Innovation of China

基　　金：湛江市科技计划项目(2018B01046)

摘　　要：目的:对比分析局部晚期宫颈癌治疗中,单纯放疗与新辅助化疗结合放疗的临床疗效。方法:选取2016年1月1日-2018年12月31日本院收治的694例宫颈癌患者为对象,采用回顾性分析方法进行研究。其中A组(n=324)新辅助放化疗结合方式,B组(n=370)单纯采用放疗形式,对两组的总缓解率、治疗前后的肿瘤直径和血小板计数情况以及不良反应发生率进行观察。结果:A组总缓解率为55.86%,B组为41.08%,A组高于B组(P<0.05)。两组治疗前肿瘤直径与血小板计数比较,差异均无统计学意义(P>0.05);两组治疗后肿瘤直径与血小板计数均优于治疗前(P<0.05),A组治疗后肿瘤直径短于B组(P<0.05),且血小板计数低于B组(P<0.05)。A组不良反应发生率为18.21%,B组为17.84%,A组略高于B组,但差异无统计学意义(P>0.05)。结论:在对局部晚期宫颈癌患者进行治疗的过程中,将新辅助化疗与放疗结合,其在提高总缓解率、缩短肿瘤直径方面效果显著,因而应用和推广价值较好。Objective:To compare and analyze the clinical efficacy of neoadjuvant chemotherapy combined with radiotherapy and radiotherapy alone in the treatment of locally advanced cervical cancer.Method:From January 1,2016 to December 31,2018,694 patients with cervical cancer admitted to our hospital were selected as subjects in this study,the data was analyzed retrospectively.Group A(n=324)was given neoadjuvant chemotherapy combined with radiotherapy,group B(n=370)was given radiotherapy.The total remission rate,tumor diameter and platelet count before and after treatment as well as the incidence of adverse reactions of two groups were observed.Result:The total remission rate of group A was 55.86%,group B was 41.08%,group A was higher than that of group B(P<0.05).There were no statistical differences in tumor diameter and platelet count between two groups before treatment(P>0.05).The tumor diameter and platelet count of two groups after treatment were shorter or less than those of before treatment(P<0.05),the tumor diameter after treatment in group A was shorter than that in group B(P<0.05).The platelet count after treatment in group A was lower than that in group B(P<0.05).The incidence of adverse reactions of group A was 18.21%,while group B was 17.84%,group A was slightly higher than that of group B,but the difference was not statistically significant(P>0.05).Conclusion:In the treatment of patients with locally advanced cervical cancer,neoadjuvant chemotherapy combined with radiotherapy has a significant effect in improving total remission rate,shortening tumor diameter,so the application and promotion value is better.

关 键 词：宫颈癌 新辅助化疗 放疗 

分 类 号：R[医药卫生]