芬吗通与补佳乐对重度宫腔粘连TCRA术后子宫内膜修复效果  

Effects of femoston and progynova for endometrial rehabilitation of patients with severe intrauterine adhesion after transcervical resection of adhesion

作　　者：马丽辉[1] 郭丽娜[1] MA Lihui;GUO Lina(The Maternal and Child Health Care Hospital of Handan City,Hebei Province,056001)

机构地区：[1]河北省邯郸市妇幼保健院

出　　处：《中国计划生育学杂志》2019年第11期1448-1451,共4页Chinese Journal of Family Planning

摘　　要：目的:分析芬吗通与补佳乐对宫腔镜下宫腔粘连分离术(TCRA)后子宫内膜修复效果。方法:选取本院妇科行TCRA手术的重度宫腔粘连患者90例,随机数字表法分为芬吗通组及补佳乐组各45例,术后分别给予芬吗通与补佳乐口服药物治疗,比较两组宫腔形态、月经恢复情况、排卵日子宫内膜状况、不良反应及妊娠情况。结果:两组术后宫腔形态恢复情况比较无差异(P>0.05),月经恢复有效率芬吗通组(84.4%)高于补佳乐组(62.2%)(P<0.05);芬吗通组术后排卵日子宫内膜厚度(9.9±2.1mm)大于补佳乐组(8.8±2.1mm),子宫内膜下血流参数RI(0.8±0.2)小于补佳乐组(0.9±0.1)(P<0.05),两组子宫内膜分型及内膜下血流参数PI及S/D无差异(P>0.05);两组术后12个月内临床妊娠率(55.6%、46.7%)无差异(P>0.05),但芬吗通组术后获得妊娠时间(5.3±2.7月)小于补佳乐组(7.0±3.3月)(P<0.05),两组不良反应发生率无差异(P>0.05)。结论:重度宫腔粘连患者TCRA术后应用芬吗通可更有效改善月经情况,增加排卵日子宫内膜厚度,缩短获得妊娠时间。Objective:To analyze the effects of femoston and progynova for endometrial rehabilitation of patients with severe intrauterine adhesion after transcervical resection of adhesion(TCRA).Methods:90 patients with severe intrauterine adhesion after TCRA were selected and were divided into the femoston group and the progynova group(45 cases in each group)according to the random number table.After surgical,the patients in femoston group were given femoston,and the patients in progynova group were given progynova.The uterine cavity morphology,menstrual recovery,uterine membrane status on ovulation day,adverse reactions rate,and pregnancy status of patients were compared between the two groups.Results:There was no statistically significant difference in postoperative uterine morphological recovery of patients between the two groups(P>0.05).The menstrual recovery efficiency of patients in femoston group was 84.4%,which was significantly higher than that(62.2%)of patients in progynova group(P<0.05).The intrauterine membrane thickness of patients on ovulation day in femoston group was 9.9±2.1mm,which was significant thicker than that(8.8±2.1mm)of patients in progynova group(P<0.05).The subendometrial blood flow parameters RI of patients in femoston group was 0.8±0.2,which was significant lower than that(0.9±0.1)of women in progynova group(P<0.05).There was no significant difference in endometrial classification subendometrial blood flow parameters(PI and S/D)of patients between the two groups(P>0.05).There was no significant difference in clinical pregnancy rate(55.6%vs.46.7%)of patients within 12 months after operation between the two groups(P>0.05).The average time from operation to pregnancy of patients in the femoston group was 5.3±2.7 mouths,which was significant shorter than that(7.0±3.3 mouths)of patients in progynova group(P<0.05),and there was no statistically significant difference in the incidence of adverse reactions of patients between the two groups(P>0.05).Conclusion:The femoston treating patients with s

关 键 词：重度宫腔粘连 宫腔镜松解术 补佳乐 芬吗通 子宫内膜修复 

分 类 号：R[医药卫生]